Overproduction of immunoglobulin E (IgE) and T helper cell type 2 (T2) cytokines, including interleukin 4 (IL-4), IL-5 and IL-13, can result in allergic disorders. Although it is known that IL-4 is critical to the polarization of nave CD4T cells to a T2 phenotype, bothand in many...
Interleukin-4 (IL-4) is a key cytokine that controls the differentiation of T helper (TH) cells to the TH2 effector cells that are responsible for cellular immunity and inflammation. Expression of the gene encoding IL-4 by T cells is regulated in two steps — the early stages of T-cell...
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized ...
IL-4-producing γδ thymocytes in normal mice belong to a distinct subset of γδ T cells characterized by low expression of Thy-1. This γδ thymocyte subset shares a number of phenotypic and functional properties with the NK T cell population. Thy-1dull γδ thymocytes in DBA/2 mice ex...
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized ...
Cutting edge: IL-4 induces functional cell-surface expression of CXCR4 on human T cells IL-4 induces functional cell-surface expression of CXCR4 on human T cells. J. Immunol. 160, 4153 -4157.Jourdan P, Abbal C, Noraz N et al. IL-4 induces functional cell-surface expression of CXCR...
Immune cells constitute a large fraction of the tumor microenvironment and modulate tumor progression. Clinical data indicate that chronic inflammation is present at tumor sites and that IL4 in particular is upregulated. Here, we demonstrate that T follicular helper (Tfh) cells arise in tumor-draini...
Here we show that an interleukin-4 fusion protein (Fc-IL-4), a typical type 2 cytokine, directly acts on CD8+ T cells and enriches functional terminally exhausted CD8+ T (CD8+ TTE) cells in the tumour. Consequently, Fc-IL-4 enhances antitumour efficacy of type 1 immunity-centric ...
JCI:IL 自然杀伤T淋巴细胞(natural killer T cells,NKT细胞)是一类同时表达恒定的T淋巴细胞受体(TCR)αβ(人为Vα24/Vβ11,鼠为Vα14/Vβ8)和NK细胞标志的T细胞亚群,主要经抗原提呈细胞表面CD1d提呈的糖脂类抗原活化,并迅速地释放大量的IFNγ和IL-4等细胞因子,通过调节Th1/Th2细胞间的平衡,在自身免疫性...
T helper (Th)1 and Th2 cells play decisive roles in the regulation of resistance vs. susceptibility to . To study the function of interleukin (IL)-4 receptor () on Th cells in , we infected specifically lacking α on (+) T cells (()α(-/) ) and α(-/) controls. ()α(-/) ...