CELL proliferationT cellsINTERLEUKINSCELL receptorsLYMPHOPROLIFERATIVE disordersInvestigates the homeostatic proliferation of T cells in lymphopaenic hosts. Role of interleukin-7 (IL-7) in the survival of hosts; Significance of T-cell receptor signalling in pathophysiologic interventions; Mediation of T-cells by IL-7.doi:10.1038/nri943NoneNature Reviews ...
Discusses the findings of studies on the role of interleukin-7 in the generation and maintenance of CD4+ memory. Methodology of the studies; Dependency of effector-memory transition on interleukin-7 signalling; Importance of interluekin-7 to central memory and effector memory cells....
这一切都足以证明IL-7/IL-15组合培养的优越性,但是在免疫细胞因子(IL-2、IFN-γ、TNF-α)或特异性裂解方面没有显著差异。在免疫缺陷的小鼠体内,如图3G所示,用IL-7/IL-15培养扩增的19BB-CAR-T细胞治疗4周后,小鼠体内的肿瘤生长明显受到抑制,小鼠的生存期明显延长。 Fig4:补用IL-7/IL-15培养的19BB-CAR-...
因此选取合适的细胞因子或者不同细胞因子搭配来培养T细胞，是增加 CAR-T免疫细胞疗效的可行方法。
CAR T cell therapy. Nat Med. 2019 Jun;25(6):947-953.【2】 Xu Y, Zhang M, Ramos CA, Durett A, Liu E, Dakhova O, Liu H, Creighton CJ, Gee AP, Heslop HE, Rooney CM, Savoldo B, Dotti G. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T ...
and C.D. Surh, IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis. Seminars in Immunology, 2012 Nguyen, Mendelsohn andLarrick, Interleukin-7 and Immunosenescence. Journal of Immunology Research, 2017 发布于 2023-10-20 09:01・北京 t细胞 B细胞 肿瘤免疫细胞治疗...
[4] Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K. IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol. 2018 Apr;36(4):346...
义翘神州已生产出高质量的重组IL-7及其受体蛋白,涵盖人、小鼠、食蟹猴和大鼠等多种属。 特色IL-7及其受体蛋白 人IL-7蛋白 Cat#: 11821-HNAE 高纯度高生物活性无标签经HPLC验证 Purity: ≥95% as determined by SDS-PAGE & HPLC Cell proliferation assay using anti-CD3 antibody activated human peripheral ...
Lin N, Tu M, Xie Y, Zhang C, Liu W, Deng L, Gao S, Ping L, Wang X, Zhou N, Zhang J, Wang Y, Lin S, Mamuti M, Yu X, Fang L, Wang S, Song H, Wang G, Jones L, Zhu J, Chen SY. A safe and potent anti-CD19 CAR T cell therapy. Nat Med. 2019 Jun;25(6):947...
【3】 Zhou J, Jin L, Wang F, Zhang Y, Liu B, Zhao T. Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects. Protein Cell. 2019 Oct;10(10):764-769. 关于同立海源 北京同立海源生物科技有限公司,成立十余年专注细胞和基因治疗(CGT)上游GMP...