Susan Kaech试图更好地表征存在于效应CD8 T细胞群体中的记忆细胞前体,并可能识别允许它们存活和发育为记忆细胞的固有细胞特性。 Figure 1. Increased expression of IL-7R directly correlates with effector CD8 T cell survival. Q:To obtain a more comprehensive understanding of memory cell development.问:为了更...
In the present study, we found a significant reduction of CD8+ T cell proportion in spleens but not in thymi of mice with T cell﹕pecific deletion of Mediator Subunit 1 (Med1). A competitive transfer of wild‐type (WT) and Med1ヾeficient CD8+ T cells reproduced the phenotype in the...
HIV CD8 T cell Immunological memory T cell memory Chronic infection IL-7rα Introduction Chronic viral infections are often associated with loss of virus-specific CD8 T cell effector functions (e.g. cytokine production or cytotoxicity) (Wherry and Ahmed, 2004). Such functional impairment has been...
T-cell memoryT-cell recirculationCD127 is the IL-7 receptor 伪-chain and its expression is tightly regulated during T-cell differentiation. We previously showed that the bone marrow (BM) is a key organ for proliferation and maintenance of both antigen-specific and CD44 high memory CD8 + T ...
In measuring T-cell receptor (TCR) repertoires of EMCD45RA+ CD8+ T cells, the elderly had a limited repertoire in IL-7Rαhigh and IL-7Rαlow cells, whereas the young had a diverse repertoire in IL-7Rαhigh but not in IL-7Rαlow cells. These findings suggest that aging affects IL-...
Virus-specific CD8 T cells expand greatly in response to viral infection and then contract to restore T cell homeostasis. How the death of these cells is regulated is not well understood. A population of CD8 T cells that maintains the ex... TW Hand,SM Kaech - 《Faseb Journal》 被引量:...
对患有疾病的hIL-7R+/+小鼠的分析显示,CD8+CD4- TCRlo胸腺细胞扩增(图5D),具有增殖表型(图5E)和胸腺大小增加(图5F)。恶性T细胞扩散至骨髓(图5D,E)和脾脏(图5D-F),表现为脾肿大(图5F)。 图5.人IL-7Rα表达导致对Bcl-2抑制敏...
1d). However, no cell loss was observed after stimulation of OT-1 CD8+ T cells with SIINFEKL peptide (N4; Fig. 1e). As stimulation of OT-I T cells with this high-affinity peptide enhances cell survival24 (Fig. 1e), we hypothesized that activation of a different survival programme ...
Kaech, S. M. et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4, 1191–1198 (2003). Silva, A. et al. IL-7 contrib...
Kaech, S. M. et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4, 1191–1198 (2003). Silva, A. et al. IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias. ...