The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4+ T cells and their differentiation to effector/memory CD4+ T cells. Mice lacking IL-7Rα have se
CD4+ T cell regulation of CD25 expression controls development of short-lived. effector CD8+ T cells in primary and secondary responses. Both CD4+ T cell help and IL-2 have been postulated to "program" activated CD8+ T cells for memory cell development. However, the linkage between these tw...
In humans, circulating CD4(+)CD25(high) T cells contain mainly regulatory T cells (Treg; FoxP3(+)IL-7Rα(low)), but a small subset is represented by activated effector T cells (Tact; FoxP3(-)IL-7Rα(high)). The balance between Tact and Treg may be important after transplantation. ...
In this study, we used conclusive loss-of-function approaches to demonstrate that IL-7R signaling is essential for T-ALL pathogenesis induced by Notch. We also show that IL-7R expression is a functional biomarker of human T-ALL cells with leukemia-initiating potential and extend this finding ...
B12 impairs IL-7/IL-7R-mediated signaling, sensitizes T-ALL cells to treatment with dexamethasone and can induce cell death per se. The antibody also promotes antibody-dependent natural killer-mediated leukemia cytotoxicity in vitro and delays T-cell leukemia development in vivo, reducing tumor ...
Although natural killer T cells (NKT cells) are thought to be generated from CD4CD8(DP) thymocytes, the developmental origin of CD4CD8(DN) NKT cells has remained unclear. In this study, we found the level of NK1.1 expression was highest in DN cells, followed by CD4 and CD8 (SP) and ...
and -21. Human and mouse IL-7 show cross-species activity through the IL-7 receptor (3, 5). IL‑7 R alpha is expressed on double negative (CD4CD8) and CD4or CD8single positive T cells as well as on CD8memory T cells and their precursors (6, 7). It is expressed early in B ...
Additionally, cell classification analysis of tumor-infiltrating immune cells (TIC) proportion showed that activated CD4+ T cells and CD8 T cells of memory B cells were positively correlated with IL-7R expression. These findings further underscored the impact of IL-7R levels on the tumor ...
Hematopoietic Progenitor Cell Markers Isolation, Culture, and Identification of Natural Killer Cells LTi Cells Lymphoid Lineage Markers Natural Killer T (NKT) Cells NCR+ILC3 NCR-ILC3 Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Cytokine Signaling...
Altogether, our data demonstrate that IL-7 promotes the extended survival of both naive and memory CD4+ T cells, whereas cycling of these two subsets is distinct and transient. Thus, IL-7 therapy should be designed to allow optimal responsiveness of naive and memory T cell subsets. 展开 ...