IL-7Rα is essential for the development and survival of naive CD4 + T cells and their differentiation to effector/memory CD4 + T cells. Mice lacking IL-7Rα have severe lymphopenia and are resistant to experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. However, ...
Interleukin-7 (IL-7) and the IL-7 receptor (IL-7R) are essential for the CD4+ T cell homeostasis by promoting survival, proliferation, and de novo production of T cells4. We and others have previously described that a single nucleotide polymorphism (SNP, rs6897932, T/C) in the gene en...
This inhibitory effect was seen in both CD4+ (Fig. 1b) and CD8+ T cells (Fig. 1c). Figure 1: TCR stimulation inhibits IL-7-mediated survival. Purified CD4+ or CD8+ T cells were stimulated in vitro and total viable cells were measured at time points indicated. (a, b) Time course...
We have previously shown in CD4 T cells that IL7Rα haplotypes 1 and 2, but not 4, respond to interferon beta (IFNβ), the most commonly used immunomodulatory drug in MS, and that haplotype 4 (Hap 4) homozygotes have the highest risk of developing MS. We now show that IL7R ...
All values in bold represent significantly increased MFI (P < .05) on AKR/J cells compared with control B10.BR cells. (C) RT-PCR analysis to investigate expression of IL-7Rα transcripts was performed by using sorted TN (CD4–CD8–TCRαβ–) thymocytes (i), B (B220+) lymphocytes (...
the overall score is positive(+).The expression of CD3d, CD4, LCK,IL-7R have showed the significant differences in the expression of glandular epithelial acinus,the positive expression of CD3 d is the highest,the expression rate is about 13.5%,and you can see the CD3d positive cells invade...
IL-7 R alpha (IL-7 receptor alpha; also CD127) is a 60-70 kDa member of the type I cytokine receptor family of molecules. It is expressed on resting naïve and memory CD8+ T cells, DN thymocytes, pre-B cells, Th1 CD4+ T cells, dendritic cells and monocytes. IL-7 R...
First, their immunophenotype varied considerably between animals (from CD4,CD8 DN to DP, to CD4 or CD8 SP cells), reflecting the different stages of maturation block known to occur in the human disease (Figure 1C).46, 47 Second, heterogeneity extended to the genetic subset of T-ALL ...
Functional and phenotypic characterizationof tetanus toxoid-specific human CD4+ T cellsfollowing re-immunization The formation of immunological memory is a hallmark of adaptive immunity and the goal of vaccination. For CD8+ T cells, successful generation of... Cristina,Cellerai,Alexandre,... - 《Eur...
Although natural killer T cells (NKT cells) are thought to be generated from CD4CD8(DP) thymocytes, the developmental origin of CD4CD8(DN) NKT cells has remained unclear. In this study, we found the level of NK1.1 expression was highest in DN cells, followed by CD4 and CD8 (SP) and ...