One key homeostatic regulator is the IL-7 receptor (IL-7R). Previous studies have shown IL-7R expression levels decrease in HIV infection, but effects on memory subtypes, CD4 T cells, and cell function have not been explored. The present study examined the expression of the IL-7Rα chain ...
The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4+ T cells and their differentiation to effector/memory CD4+ T cells. Mice lacking IL-7Rα have se
结果 免疫组织化学检测结果显示LGBLEL组CD3d、CD4、LCK、IL-7R蛋白表达均呈阳性;CD3d在淋巴滤泡周围阳性表达率高达85.5%,在淋巴滤泡间区阳性表达率高达51.8%,总体积分值为强阳性(++++);CD4在淋巴滤泡周围阳性表达率高平均约54.6%,在淋巴滤泡间区阳性表达率高达22.5%,总体积分值为阳性(+++);LCK在淋巴滤泡周围...
IL-7Rα is essential for the development and survival of naive CD4+ T cells and their differentiation to effector/memory CD4+ T cells. Mice lacking IL-7Rα have severe lymphopenia and are resistant to experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. However, it ...
The loss of IL-7Rα in CD4 + T cells led to a gradual and substantial decrease in their numbers in both non-immunized and immunized CD4 Δ Il7ra mice, followed by slow repopulation up to the initial numbers. CD4 Δ Il7ra mice did not develop EAE. We found a decrease in the total...
Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice. J. Exp. Med. 204 : 619-631... LC Osborne,S Dhanji,JW Snow,... - 《Journal of Experimental Medicine》 被引量: 140发表: 2007年 The biological role of IL-7Ralpha Y449 signaling in lymphocyte de...
IL7RA polymorphisms predict the CD4+ recovery in HIV patients on cART. Eur J Clin Invest. 2015; 45(11):1192-9. https://doi.org/10.1111/eci.12539 PMID: 26402121.Guzman-Fulgencio, M. et al. IL7RA polymorphisms predict the CD4+recovery in HIV patients on cART. Eur. J. Clin. ...
IL-7Rα is essential for the development and survival of naive CD4 + T cells and their differentiation to effector/memory CD4 + T cells. Mice lacking IL-7Rα have severe lymphopenia and are resistant to experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. However, ...
CD4(+) T cellsCIAT cell response is crucial to the pathogenesis and progression of rheumatoid arthritis (RA). IL-7/IL-7R axis has significant effect on CD4(+) T cell response, including proliferation, differentiation, survival and migration. However, whether blockade of IL-7/IL-7R axis ...
表达约13.5%,并可见CD3d阳性细胞侵入腺泡现象,CD4阳性表达率次之,表达约4.5%,偶见侵入腺泡现象.LCK,IL-7R在腺泡的表达均呈阴性,未见侵入腺泡现象.眼眶海绵状血管瘤组CD3d,CD4,LCK,IL-7R表达均呈阴性.结论 CD3d,CD4,LCK,IL-7R因子在LGBLEL病变组织中的表达异常,CD3d,CD4,LCK,IL-7R因子参与了LGBLEL的发病...