The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4+ T cells and their differentiation to effector/memory CD4+ T cells. Mice lacking IL-7Rα have se
结果 免疫组织化学检测结果显示LGBLEL组CD3d、CD4、LCK、IL-7R蛋白表达均呈阳性;CD3d在淋巴滤泡周围阳性表达率高达85.5%,在淋巴滤泡间区阳性表达率高达51.8%,总体积分值为强阳性(++++);CD4在淋巴滤泡周围阳性表达率高平均约54.6%,在淋巴滤泡间区阳性表达率高达22.5%,总体积分值为阳性(+++);LCK在淋巴滤泡周围...
We hypothesized that T-allele homozygosity (‘TT’) compared to C-allele homozygosity (‘CC’) in rs6897932 increases the binding of IL-7, increases the intracellular signaling of the IL-7R, and increases the IL-7R response in CD4+ T cells. To investigate this, the binding of biotinylated...
Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism IS related to CD4+ recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4+ T-cells count. We aim
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IL-7Rα is essential for the development and survival of naive CD4 + T cells and their differentiation to effector/memory CD4 + T cells. Mice lacking IL-7Rα have severe lymphopenia and are resistant to experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. However, ...
IL7RA polymorphisms predict the CD4+ recovery in HIV patients on cART. Eur J Clin Invest. 2015; 45(11):1192-9. https://doi.org/10.1111/eci.12539 PMID: 26402121.Guzman-Fulgencio M, Berenguer J, Jimenez-Sousa MA, Micheloud D, Garcia- Alvarez M, Bellon JM, et al. IL7RA polymorphisms...
IL7rα Expression on CD4 + T Cells, but Not on Other Cells is Essential for the Development of Chronic Colitisanticipatory guidancechild developmentinfancyparentingpreventionrelationshipsystemTouchpointstrainingThis paper describes a study conducted in Israel which focuses on how studying industrial chemistry...
A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. Bayer AL,Lee JY,de la Barrera A,Surh CD,Malek TR. J Immunol . 2008Bayer, A.L., et al., A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol, 2008. 181(1):225-234....
Membrane-associated IL-7R expression on CD4+ and CD8+ T cells.Christian, LundtoftAnthony AfumAdjei, AwuahJens, RimplerKirstin, HarlingNorman, NauschMalte, KohnsErnest, AdankwahFranziska, LangLaura, OlbrichErtan, Mayatepek