基于每个簇中的高表达基因以及转录因子对簇进行判断: 簇0的特征是转录因子(TFs) TCF7(编码TCF1)、LEF1和FOXO1的表达,存活相关基因(IL7R)、共刺激分子(CD28、CD27、FAS和CD226)的表达较高,但CD38的表达不高。 簇1的基因转录本包括tf BCL6、MAF和TOX2,以及与B细胞辅助功能相关的
One key homeostatic regulator is the IL-7 receptor (IL-7R). Previous studies have shown IL-7R expression levels decrease in HIV infection, but effects on memory subtypes, CD4 T cells, and cell function have not been explored. The present study examined the expression of the IL-7Rα chain ...
进一步分析表明,肿瘤浸润的CD4+ T28zT2细胞高表达TCF-1、IL7R和CXCR3,呈现记忆样T细胞特征,同时上调NKG2D并降低PD-1/LAG3等耗竭标志物,显著增强其抗肿瘤活性。此外,CD4+ T28zT2细胞能够重塑肿瘤微环境,协同增强靶向GPC3或MSLN的CD8+...
将炎症动脉内的T细胞从血管外淋巴组织(主要是NSG小鼠的脾脏)中分离出来,我们将炎症动脉细胞连续移植到“空”小鼠中,而没有移植其他的人类细胞(图8D)。监测原发性和继发性接受者血液和脾脏中的人类T细胞数量(图8E)。通过组织学评分,评估炎症的严重程度和扩散以及血管损伤的程度,IL-7R+细胞的PBMCs诱导的血管炎严重...
然而,其他途径必然也是重要的,因为缺乏 IL - 2Rβ 的小鼠同样会经历克隆扩增和收缩,而强制表达 IL - 7Rα 的小鼠也无法从克隆收缩中得到解救。 第二种可导致效应 T 细胞死亡的机制由肿瘤坏死因子受体超家族成员(如 Fas(CD95))所介导的信号激活,其能够激活细胞凋亡的外在(或死亡受体)途径(extrinsic (or death...
4a). The inferred trajectory agreed with the time points profiled experimentally, and T cell activation markers such as IL7R (reduced expression upon activation), CD69 (early activation) and IL2RA (early and late activation) (Fig. 4b) also followed their expected expression patterns. In total...
Furthermore, ‘TT’ individuals had increased proliferation of CD4+ T cells after culture with IL-7 plus sIL-7RA. No differences between ‘TT’ and ‘CC’ individuals were found in IL-7 binding to IL-7R and viability of PBMC. These data suggest enhanced intracellular signaling and increased...
在连续移植实验中,表达白细胞介素7受体(IL-7R)的TCF1hiCD4+ T细胞持续发生血管炎。因此,TCF1hi CD4+ T细胞作为疾病干细胞,促进自身免疫性组织炎症的慢性和自主性进展,所以治疗将需要靶向干细胞样CD4+ T细胞,而不是仅仅针对效应T细胞。 技术服务 单细胞转录组学测序、单细胞TCR免疫组库测序、RNA-seq 研究内容1....
继续分析相关差异基因发现CD4-Runx3细胞叛变了,高表达CD8相关基因如CD101,Cdh1,Xcl1,Rgs2,Cmah以及Litaf等,而低表达IL7r,Ly6c和S1pr1。分析CD4-Runx3和已经发表的CD8 Trm特征分子发现两者共享很多相关的基因,这表明Runx3诱导了CD4 T细...
CD4_markers_step1=list(T_check=c("CD3D","CD3E","CD4",'CD8A',"PTPRC"),Treg=c("TNFRSF4","BATF","TNFRSF18","FOXP3","IL2RA","IKZF2","IL7R"))genes_to_check=lapply(CD4_markers_step1,function(x)str_to_upper(x))DotPlot(sce,features=genes_to_check)+#coord_flip()+theme(axi...