The effect of nicotine exhausting CD8 T cells was investigated in vitro and in the humanized tumor xenografts in vivo. We found that CD8 T cells were able to reduce cell viability in lung cancer HCC827 and A549 cells, that secreted granzyme B, but CD8 T cells from the healthy cigarette ...
The effect of nicotine exhausting CD8(+) T cells was investigated in vitro and in the humanized tumor xenografts in vivo. We found that CD8(+) T cells were able to reduce cell viability in lung cancer HCC827 and A549 cells, that secreted granzyme B, but CD8(+) T cells from the ...
Additionally, the dysregulated mutant IL-2R尾-driven CD8+ T cell immunophenotype normalized but the NK phenotype did not. These data highlight the asymmetrical effect that a partial IL-2R尾 defect has on CD8 T and NK cell IL-2/15-dependent signaling and downstream cellular processes. These ...