近日，美国华整顿大学医学院Marion Pepper团队在Immunity杂志发表了题为Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers的文章。作者发现GCB细胞中的IL-4细胞因子信号通过负向自动调节直接下调转录因子BCL6，从而将细胞从GCB程序中释放并促进MBC的形成，这会...
一、IL-4的功能 白介素4具有许多生物学作用,包括刺激活化的B细胞和T细胞 增殖,以及将B细胞分化为浆细胞。它是体液和适应性免疫的关键调节剂。IL-4诱导B细胞类别转换为IgE,并上调MHC II类产生。IL-4减少Th1细胞,巨噬细胞,IFN-γ和树突状细胞 IL-12的产生。 IL-4的过量生产与过敏有关。 炎症和伤口修复:组织...
近日,美国华整顿大学医学院Marion Pepper团队在Immunity杂志发表了题为Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers的文章。作者发现GCB细胞中的IL-4细胞因子信号通过负向自动...
Further investigation showed that IL4 (interleukin 4), a key effector Th2 cytokine in allergic asthma, was critical for autophagy induction in B cells both in vivo and in vitro, which further sustained B cell survival and enhanced antigen presentation by B cells. Moreover, IL4-induced ...
该研究进一步证实,已获得FDA批准的IL-4阻断药物dupilumab(用于治疗哮喘和特应性皮炎)与抗PD-1单抗联用,可增强卵巢癌免疫治疗效果。 早在2022年3月,该团队在Cell期刊发表论文【2】,开发了一种新型空间功能基因组学筛选技术——Perturb-...
BSF1; BCGF1 ;B Cell Stimulatory Factor 1; Lymphocyte stimulatory factor 1; B Cell Growth Factor; Binetrakin; Pitrakinra |IL-4 简介 白细胞介素4(IL-4)是一种多效应细胞因子,主要由嗜碱性粒细胞、嗜酸性粒细胞、肥大细胞和Th2细胞等多种细胞分泌,在许多细胞中均能够发挥免疫调节功能。IL-4作为B细胞的...
Cell proliferation assay using anti-CD3 antibody activated human peripheral blood mononuclear cell (PBMC) 高批间一致性 Cell proliferation assay using anti-CD3 antibody activated human peripheral blood mononuclear cell (PBMC) 【参考文献】 Barata, Durum and Seddon, Flip the coin: IL-7 and IL-7R in...
, macrophages, IFNγ, and dendritic cell IL-12. Like other Th2 associated cytokines, IL-4 is involved in the airway inflammation observed in the lungs of patients with allergic asthma. The 11B11 monoclonal antibody has been shown to neutralize the bioactivity of natural or recombinant IL-4....
IL-4 Protein, Human MCE 国际站:IL-4 Protein, Human IL-4 Protein, Human是一种有效的淋巴细胞生长因子,刺激 B 细胞增殖分化,参与炎症反应。 Synonyms: Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4 Species: Human Source: ...
4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunological class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. It can promote survival, growth, and differentiation of both T and B lymphocytes, mast ...