近日，美国华整顿大学医学院Marion Pepper团队在Immunity杂志发表了题为Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers的文章。作者发现GCB细胞中的IL-4细胞因子信号通过负向自动调节直接下调转录因
近日,美国华整顿大学医学院Marion Pepper团队在Immunity杂志发表了题为Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers的文章。作者发现GCB细胞中的IL-4细胞因子信号通过负向自动...
一、IL-4的功能 白介素4具有许多生物学作用,包括刺激活化的B细胞和T细胞 增殖,以及将B细胞分化为浆细胞。它是体液和适应性免疫的关键调节剂。IL-4诱导B细胞类别转换为IgE,并上调MHC II类产生。IL-4减少Th1细胞,巨噬细胞,IFN-γ和树突状细胞 IL-12的产生。 IL-4的过量生产与过敏有关。 炎症和伤口修复:组织...
Further investigation showed that IL4 (interleukin 4), a key effector Th2 cytokine in allergic asthma, was critical for autophagy induction in B cells both in vivo and in vitro, which further sustained B cell survival and enhanced antigen presentation by B cells. Moreover, IL4-induced ...
该研究进一步证实,已获得FDA批准的IL-4阻断药物dupilumab(用于治疗哮喘和特应性皮炎)与抗PD-1单抗联用,可增强卵巢癌免疫治疗效果。 早在2022年3月,该团队在Cell期刊发表论文【2】,开发了一种新型空间功能基因组学筛选技术——Perturb-...
We observed a marked disorganization of B cells in these mice, suggesting that the lymphocyte-stromal cell axis is maintained by the IL-4 signaling pathway. This study showed that absence of IL-4 correlates with significant downregulation of Lymphotoxin alpha (LT伪) and Lymphotoxin beta (LT尾)...
PeproTech重组大鼠IL-4/400-04 产地:美国 品牌: PeproTech 货号: 400-04 数量: 大量 保质期: 1年以上 规格:2µg/10µg/1mg 英文名: Recombinant Rat IL-4 保存条件: -20o℃ 供应商: 深圳子科生物科技有限公司 Synonyms : BCGF, BCDF, B cell stimulating factor (BSF-1) Description : ...
B cells subsequently regulate the adaptive immune response by enhancing CD4+ T cells Inducible T cell Costimulator (ICOS) expression on CD4+ T cells and amplifying both Th2 cell and T follicular helper cell induction. Antibody blockade of ICOS ligand, expressed by PLN B cells but not DC at ...
6月6日,宾夕法尼亚大学Christopher A. Hunter、Drew Weissman通讯在《Science immunology》发表论文“An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses”,发现虽然内源性IL-12对mRNA-LNP疫苗的CD8 T细胞启动非必需,但共递送编码IL-12的mRNA-LNP(LNP–IL-12)可显著增强疫苗诱导的...
6月6日,宾夕法尼亚大学Christopher A. Hunter、Drew Weissman通讯在《Science immunology》发表论文“An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses”,发现虽然内源性IL-12对mRNA-LNP疫苗的CD8 T细胞启动非必需,但共递送编码IL-12的mRNA-LNP(LNP–IL-12)可显著增强疫苗诱导的...