Expression of the gene encoding IL-4 by T cells is regulated in two steps — the early stages of T-cell differentiation and the later stage of acute gene expression by differentiated TH2 effector cells. During
IL-4-producing γδ thymocytes in normal mice belong to a distinct subset of γδ T cells characterized by low expression of Thy-1. This γδ thymocyte subset shares a number of phenotypic and functional properties with the NK T cell population. Thy-1 dull γδ thymocytes in DBA/2 mice ...
2. In particular, IL-4 promotes humoral responses whilst dampening cell-mediated activity, including via type 2 helper T cell lineage commitment and maintenance1,3,4. Consequently, its production and signalling has been implicated in many different pathologies...
STAT Transcription Factor T Cell Factor (TCF) IL-4 STAT6 T Helper Cells Introduction The transcription factors TCF-1 (T cell factor 1) and LEF-1 (lymphoid enhancer-binding factor 1) are downstream effectors of the canonical Wnt pathway, also known as the Wnt-β-catenin signaling pathway (...
所谓T细胞耗竭(T Cell Exhaustion)就是指常见慢性感染和癌症患者体内T细胞功能丧失。由于长期暴露于持续性抗原或慢性炎症,疲惫的T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。不过这种耗竭是可以逆转的,至少部分逆转,主要是通过阻止PD-1之类的抑制性通路。 TEx Are a...
近日,华东师范大学生命科学学院、上海市调控生物学重点实验室刘明耀教授、杜冰教授团队在Cancer Cell杂志上发表了题为CAR-T therapy in solid tumors的综述,汇总了目前CAR-T细胞在多种实体瘤临床研究中的突破性进展,探讨了CAR-T细胞在治疗实...
Engineering strategies to overcome the current roadblocks in CAR T cell therapy. Clinical Oncology. 3. Harrison, et al. Enhancing co-stimulation of CAR T cells to improve treatment outcomes in solid cancers. Immunotherapy Advances. 4. Glover, et al. How Can We Engineer CAR T Cells to ...
摘要TPS708:New phase 1 SURPASS trial cohort: Early-line ADP-A2M4CD8 T-cell receptor T-cell therapy plus pembrolizumab in urothelial carcinoma. 研究背景:ADP-A2M4CD8 T细胞受体(TCR) T细胞治疗包括对自身CD4+和CD8+ T细胞进行基因修饰,靶向黑色素瘤相关抗原A4(MAGE-A4),用于符合人类白细胞抗原A*02条件...
Interestingly, SCID recipients of either wt or IL-4−/− RBHi T cells showed mild lesions in the stomach, with only slight cell infiltration. Adoptive transfer of wt or IL-4−/− CD45RBlow T cells did not result in gastritis, duodenitis, or colitis (data not shown). Download: ...
关键时刻,医生从细胞因子测试中发现异常升高的IL-6(白细胞介素-6),决定尝试托珠单抗。奇迹随之发生:用药后病情迅速好转,治疗23天后,艾米莉体内癌细胞完全消失,实现“临床治愈”。2012年6月,7岁的艾米莉出院时,近千人聚集在她的小镇,以盛大的仪式欢迎这位抗癌小英雄回家。如今,她已创下无癌生存13年的长生存纪录!