How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ 2018; 25(1):104-113.Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death ...
How can p53 induce differentiation of leukemic cells? Moreover, p53 can induce differentiation of U-937-4 cells in spite of inhibition of p53-mediated apoptosis as mediated by bcl-2. Also, the amount of... K Drott - 《Dept of Hematology C14 Bmc Lund Sweden》 被引量: 0发表: 2001年 Ch...
The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Brandon J Aubrey, Gemma L Kelly, Ana Janic, Marco J Herold & Andreas Strasser Cell Death & Differentiation volume 25, pages104–113(2018)Cite this article ...
Similar to CD95L, IFN-I have been shown multiple times to induce apoptosis in cancer cells by activating both the extrinsic and the intrinsic apoptosis pathways45. Data on the pro-death activities of IFNs and CD95 were initially obtained by using apoptosis sensitive cells stimulated for a ...
Apoptosis is a central part of normal development. Under some circumstances, however, apoptosis can also be seen in response to a number of abnormal stimul... WG Mckenna,RJ Muschel - 《European Journal of Cancer》 被引量: 792发表: 1995年 Membrane insertion: The strategies of toxins (Review)...
Mesenchymal stem/stromal cells (MSCs) have emerged as a promising tool in the field of regenerative medicine due to their unique therapeutic properties as they can differentiate into multiple cell types and exert paracrine effects. However, despite encouraging results obtained in preclinical studies, cl...
on 7-DHC's potential to induce a death-resistant state in tumors, ultimately contributing to a more aggressive cancer phenotype. This discovery unveils a previously unrecognized anti-ferroptotic activity of 7-DHC, presenting a cell-intrinsic mechanism that cancer cells might exploit to evade death...
Further investigation revealed that caspase cleavage of ROCK1 yields a constitutively active kinase fragment that is sufficient to induce membrane blebbing resembling that seen in apoptotic cells. In addition, the cleaved ROCK1 fragment appears to be important for disruption of nuclear integrity and the...
Long-lived plasma cells are generated in response to T cell–dependent antigens during the germinal center reaction and are primarily found in the bone marrow, where stromal cells provide specific niches supporting their retention and survival15. The maximal life-span of bone-marrow plasma cells ...