Questions how apoptosis is regulated and what goes wrong in cancer. Details of programmed cell death, or apoptosis, an evolutionarily conserved pathway needed for embryonic development and tissue homoestasis; How the most studied genes related to apoptosis are the tumour suppressor gene, the anti-...
Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related death worldwide, with an overall 5-year survival rate of only 10-15%. Deregula... MR Junttila,AN Karnezis,D Garcia,... - 《Nature》 被引量: 365发表: 2010年 p53 and apoptosis One of the several biological ...
Although evasion of apoptosis is thought to be required for the development of cancer, it is unclear which cell death pathways are evaded. We previously id... J Thorburn,F Moore,A Rao,... 被引量: 294发表: 2005年 Eukaryotic V-ATPase: Novel structural findings and functional insights The eu...
Neoadjuvant chemotherapy has traditionally been used to treat locally advanced and initially inoperable breast cancer. One of the main reasons for applying a systemic therapy before rather than after curative surgery is the potential size reduction of a malignant tumor, which is thought to permit less...
2021, Cancer Treatment and Research Communications Citation Excerpt : Angiogenesis is mediated by a mediator's secretion called vascular endothelial growth factor (VEGF) [50]. The hypoxia-inducible factor is the master that controls different biological changes in GBM, ranging from angiogenesis to treat...
Korean scientists found that HVH-2930, an innovative HSP90 inhibitor, demonstrates promising efficacy in inducing cancer cell apoptosis and overcoming treatment resistance in HER2-positive breast cancer. Unlike previous HSP90 inhibitors, the compound circumvents limitations by bypassing heat shock response ...
Apoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malignant clones. However, over the years, ...
Additionally, the ability of HIF-1α to enhance the survival of MSCs is attributed to its interaction with Bcl-2, a protein capable of inhibiting apoptosis and regulating cell proliferation, by binding with a hypoxia-response element in the Bcl-xL promoter [42]. On the other hand, Lan et ...
These problems include –but not limited to: low solubility in water, low bioavailability, high toxicity and instability. Nanotechnology has shown great promise for many medical applications such as cancer diagnosis, chemotherapeutic drug delivery, and diabetes treatments [29]. This technology is ...
Apoptosis, especially the intrinsic mitochondrial cell death pathway, is regulated by the BCL-2 family of proteins. Defects in apoptotic machinery are one of the main mechanisms that cells employ to evade cell death and become cancerous. Targeting the apoptotic defects, either by direct inhibition ...