Rather than leaving a cell that is fundamentally prevented from undergoing apoptosis, very often the resulting cancer cell is quite ready to undergo apoptosis compared to normal cells. This distinction is, indeed, an important determinant of the therapeutic index for conventional chemotherapy that we ...
Over the past decade, cancer stem cells have emerged as the centerpiece of cancer research, having a major role in resistance to conventional therapy and in the metastatic spread of tumours. The authors discuss the biological complexity of this subpopula
Conversely, it can lose a substantial percentage of its mass, strength and cross-sectional area in response to a range of insults, many of clinical importance, including immobility, starvation, denervation, sepsis, glucocorticoids, tenotomy, cancer cachexia, weightlessness, cardiac failure, diabetes, ...
afor a-smooth muscle actin in serial sections. Several anti-Fas:APO 1 positive foam cells were revealed to undergo apoptosis by[translate] a利用机械系统动力学分析软件(ADAMS)对工作臂进行运动分析和仿真 Uses mechanical system dynamics analysis software (ADAMS) to carry on the movement analysis and ...
Expression and function of several integral PM and PM-associated proteins, which are not randomly distributed over the PM but instead confined to cholesterol- and sphingolipid-rich nanodomains, are altered in cancer cells [155,156,157,158,159]. Moreover, it has been shown that cholesterol ...
Liriodenine dramatically lowered cellular vitality, caused apoptosis, enhanced the development of apoptotic nucleoli, and enhanced caspase-3 activity in MCF-7 cells, according to the findings. On human lung cancer cells (Chang et al., 2004) and human ovarian cancer cells, liriodenine has ...
Bonetti B & Raine CS (1997) Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis. Ann. Neurol. 42: 74–84.Bonetti B. and Raine C. S. ( 1997 ) Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do ...
Most viruses enter through multiple receptors and undergo viral latency and genetic instability, which leads to the failure to produce high-efficiency vaccines. Chemotherapy is being used as the primary treatment against cancer. Still, its inability to completely eliminate cancer stem cells is of ...
How does caspases regulation play role in cell decisions? apoptosis and beyond Negar Ghorbani Roham Yaghubi Sara Pahlavan Molecular and Cellular Biochemistry(2024) BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors ...
Many neurons undergo apoptosis following injury, especially if the lesion is close to their cell bodies. Presumably, this was because axotomized neurons are deprived of the trophic support which is normally provided 819 820 Bcl-2 in the regulation of nerve regeneration DF Chen and S Tonegawa by ...