Both cell-mediated immunotherapy and immune-checkpoint inhibition induce apoptosis in cancer cells through the extrinsic pathway; the possibility of potentiating this effect using combination regimens (involving targeted therapies, cytotoxic agents or radiotherapy) is currently under investigation. This is a ...
The present invention provides nucleobase oligomers and oligomer complexes that inhibit expression of an IAP polypeptide, and methods for using them to induce apoptosis in a cell. The nucleobase oligomers and oligomer complexes of the present invention may also be used to form pharmaceutical ...
Further, the present invention provides pharmaceutical compositions and methods for the treatment of suffering from leukemia or other forms of cancer in a mammal or for the treatment of cells programmed cell death caused by the disease symptoms. 4-[3-(1-金刚烷基)-4-羟基苯基]-3-氯肉桂酸(3-...
《Inhibition抑制 of mTORC1 by astrin胃泌素 and stress granules应激颗粒 prevents apoptosis凋亡 in cancer cells》 1. Astrin与mTOR竞争以结合raptor。表现在如果astrin缺失,那么mTORC1会形成得更多。 2. 可以解答为什么我的研究计划中要用到亚硝酸盐Thus, formation of the raptor-astrin complex and its associatio...
Muscle fructose-1,6-bisphosphate aldolase (ALDOA) is among the most abundant glycolytic enzymes in all cancer cells. Here, we show that the enzyme plays a previously unknown and critical role in a cancer cell survival. Simultaneous inhibition of ALDOA ac
In summary it can be suggested that suppressing the survivin protein expression, boosting ROS and NO level by CP or other pharmaceutical agent may be an effective way in controlling the malignancy in human prostate cancer cells.doi:10.1002/cbin.10328Mina Sattari...
Cells were counted and DNA diffusion assay was used to evaluate apoptosis and necrosis in each sample at 0 h and at 1, 2, 4 and 8 h of incubation. RESULTS: DHA treatment significantly decreased cell counts and increased the proportion of apoptosis in cancer cells compared to controls (chi2...
In silico analysis revealed AEG-1 and BCL2 to be the potential targets of miR-136. Therefore, the expression of AEG-1 and BCL2 was determined in untreated control, cisplatin treated control and miR-136 transfected AGS gastric cancer cells. The results revealed that overexpression of miR-136 ...
cervical cancer cells expressing HPV18 expressing Δ133p53 isoforms failed to show enhanced apoptosis.54 Furthermore, the presence of a splice mutation at intron 4 (c.375+1G>A) in high-grade serous ovarian cancers at the time of diagnosis has also been associated with platinum-resistance after ...
Cancer cells with high procaspase-3 expression, like HL-60 and U-937, were particularly sensitive. WF-210-induced the apoptosis of HL-60 and U-937 cells by activating procaspases and promoting proteasome-dependent degradation of XIAP and Survivin. The level of WF-210-induced apoptosis in ...