How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ 2018; 25(1):104-113.Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death ...
Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288: 1053–1058. Article CAS PubMed Google Scholar Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B . PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell ...
Although p53-mediated cell-cycle arrest, senescence and apoptosis serve as critical barriers to cancer development, emerging evidence suggests that the metabolic activities of p53 are also important. Here we show that p53 inhibits cystin... J Le,K Ning,T Li,... - 《Nature》 被引量: 281发表...
alternative oxidase that enables electron flow and ATP generation but does not produce ROS. As anticipated, these macrophages showed reduced mtROS production without ETC disruption. Despite the lack of mtROS production, these cells displayed NLRP3 activation similar to that of wild-type cells, and ...
Explain how cells regulate the process of mitosis. Describe in detail the phases of mitosis. What is the most basic purpose of mitosis and the cell cycle? How does the cell control these processes? What are checkpoints and apoptosis?
11. People with Cancer in their family history must make sure that they include Ginger in their regular eating as Ginger posses anticancer properties and has proven to aid the process of Apoptosis in cells which are becoming abnormal and can lead to Cancer. ...
bcl‐2 and bak may play a pivotal role in sodium butyrate‐induced apoptosis in colonic epithelial cells; however overexpression of bcl‐2 does not protect against bak‐mediated apoptosis Butyrate, a short chain fatty acid produced in the colon as a result of fermentation of dietary fibre by ...
Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying cells and cell debris, immune complexes, bacteria and other waste products. Simultaneously, they produce growth factors and signalling molecules
(NK) cells via a mechanism which does not appear to involve TLR-4 activation on APCs [105], and there are replicated data indicating that the presence of this antigen stimulates the proliferation of CD56+CD3−NK cells, which appear to play a role in the pathogenesis of AD [106,107]; ...
(I\) (right) vs reciprocal % change (relative to WT) of effector function, i.e., the peptide dose required for 3.L2 T cells to generate 40% B cell apoptosis (1/EC40)37 (red) or the area under the dose response curve (AUC) of the 2B4 hybridoma IL-2 production38 (blue) plots...