(57) I will disclose the methods and compositions to induce apoptosis and differentiation in cells overexpressing [summary] Notch protein. Cell fate determination function of Notch, it is specifically destroyed at a time when the cells are being differentiated, cells trigger apoptosis by this. It ...
How can p53 induce differentiation of leukemic cells? Moreover, p53 can induce differentiation of U-937-4 cells in spite of inhibition of p53-mediated apoptosis as mediated by bcl-2. Also, the amount of... K Drott - 《Dept of Hematology C14 Bmc Lund Sweden》 被引量: 0发表: 2001年 Ch...
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Brandon J Aubrey, Gemma L Kelly, Ana Janic, Marco J Herold & Andreas Strasser Cell Death & Differentiation volume 25, pages104–113(2018)Cite this article ...
The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly
howbh3-onlyproteinsinduceapoptosis 系统标签: proteinsapoptosisinducenoxabimbax Lifeinthebalance:howBH3-onlyproteinsinduceapoptosisSimonNWillisandJerryMAdamsBH3-onlymembersoftheBcl-2intracellularproteinfamily,whichincludeBim,Bmf,Bik,Bad,Bid,Puma,NoxaandHrk,mediatemanydevelopmentallyprogrammedandinducedcytotoxicsignals...
The latter are biologically active secondary plant metabolites, many of which modify cell proliferation and induce apoptosis in vitro. There is growing ... IT Johnson - 《Mutat Res》 被引量: 375发表: 2004年 History of the events leading to the formulation of the apoptosis concept. Histological...
Additionally, the ability of HIF-1α to enhance the survival of MSCs is attributed to its interaction with Bcl-2, a protein capable of inhibiting apoptosis and regulating cell proliferation, by binding with a hypoxia-response element in the Bcl-xL promoter [42]. On the other hand, Lan et ...
In stressed cells, apoptosis ensues when Bcl-2 family members Bax or Bak oligomerize and permeabilize the mitochondrial outer membrane. Certain BH3-only relatives can directly activate them to mediate this pivotal, poorly understood step. To clarify the conformational changes that induce Bax oligomeriza...
REVIEW Can successful vaccines teach us how to induce efficient protective immune responses? Paul-Henri Lambert1, Margaret Liu2 & Claire-Anne Siegrist1 Some recently introduced vaccines that have excellent efficacy records have been developed without a clear understanding of their mechanism of protection...
are able to identify and kill cancerous cells without the need to detect MHC receptors. Once they target one of these cells, Cytotoxic T cells use perforins, granzymes, and proteases, or even FAS ligand signaling to trigger the caspase cascade and induce apoptosis in the unhealthy cell. Both...