How can p53 induce differentiation of leukemic cells? Moreover, p53 can induce differentiation of U-937-4 cells in spite of inhibition of p53-mediated apoptosis as mediated by bcl-2. Also, the amount of... K Drott - 《Dept of Hematology C14 Bmc Lund Sweden》 被引量: 0发表: 2001年 Ch...
The caveat with the aforementioned experiments is that the levels of p53 used to induce apoptosis were abnormally high. Hence, it was not yet proven that p53 could induce apoptosis under physiological conditions, that is, when expressed at normal levels. This was established when it was shown ...
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Brandon J Aubrey, Gemma L Kelly, Ana Janic, Marco J Herold & Andreas Strasser Cell Death & Differentiation volume 25, pages104–113(2018)Cite this article ...
Mesenchymal stem/stromal cells (MSCs) have emerged as a promising tool in the field of regenerative medicine due to their unique therapeutic properties as they can differentiate into multiple cell types and exert paracrine effects. However, despite encouraging results obtained in preclinical studies, cl...
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ 2018; 25(1):104-113.Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death ...
Angiogenesis is mediated by a mediator's secretion called vascular endothelial growth factor (VEGF) [50]. The hypoxia-inducible factor is the master that controls different biological changes in GBM, ranging from angiogenesis to treatment resistance [53]. Both HIF and VEGF work together to promote...
Further investigation revealed that caspase cleavage of ROCK1 yields a constitutively active kinase fragment that is sufficient to induce membrane blebbing resembling that seen in apoptotic cells. In addition, the cleaved ROCK1 fragment appears to be important for disruption of nuclear integrity and the...
Recruitment of CTLs into bone marrow was found to be elevated in ITP patients due to increased expression of VLA-4 and CX3CR1 [60]. Additionally, the abnormal bone marrow microenvironment as demonstrated by defects in mesenchymal stem cells and endothelial progenitor cells [61,62,63], ...
A major problem in the search for new cancer drug targets is that the drugs are often toxic to normal tissues and require high doses to kill tumor cells. T... C Mothersill,C Seymour - 《Current Cancer Drug Targets》 被引量: 162发表: 2006年 Lovastatin protects human endothelial cells fro...
or even FAS ligand signaling to trigger the caspase cascade and induce apoptosis in the unhealthy cell. Both helper T cells and cytotoxic T cells release cytokines when activated. These extracellular cytokine signals can recruit and cue the proliferation of other lymphocytes to bolster the immune res...