Cells depend on specific stimuli, such as trophic factors, for survival and in the absence of such stimuli, undergo apoptosis. How do cells initiate apoptosis in response to the withdrawal of trophic factors or other dependent stimuli? Recent studies of apoptosis induction by neurotrophin withdrawal...
Cell death is important for maintaining cell number and preventing aberrant cell growth, which leads to cancer. There are three mechanisms of cell death: necrosis, asutophagy and apoptosis.Answer and Explanation: CTL and NK cells induce apoptosis through the Fas mediated signalling pathway....
Do memory cells undergo apoptosis? During the primary immune response, memory cells do not respond to antigens and do not contribute to host defenses. As the infection is cleared and pathogenic stimuli subside, the effectors are no longer needed, and theyundergo apoptosis. ... As a result, m...
How do CTL and NK cells cause other cells to undergo apoptosis? How is compartmentalization and specialization within cells more energetically efficient? Discuss how CatSper channels are activated and what Ca^{2+} does once it enters into the cell. ...
This nuclear protein stays contained within the nucleus during apoptosis, but is released when cells undergo necrosis (Raucci et al., 2007). Currently, this is typically done by analyzing the supernatant for HMGB1, or by microscopy. This would be an excellent assay to implement on a tool like...
Apoptosis Necrosis Tumor suppressor protein Cells that cannot undergo apoptosis and aren't damaged enough to undergo necrosis Skills Practiced Reading comprehension- ensure that you draw the most important information from the related biology lesson Interpreting information- verify that you can read...
For example, chronic lymphocytic leukemia cells survive well in a lymph-node niche in vivo but rapidly undergo apoptosis ex vivo. This indicates that (i) the downstream apoptosis machinery is usually functional in these cells, and, that (ii) they are ready-to-die and as such strictly ...
This can be explained if the tubulin subunits undergo a lengthwise conformational change that is the sum of two components — a 0.11 nm overall expansion that does not affect LN and a local 0.04 nm change that does. Taxol influences microtubule assembly and growth Figure 6 shows images of ...
Remarkably, even mice lacking all mediators critical for p53-induced apoptosis, G1/S boundary cell cycle arrest and cell senescence do not develop any tumours spontaneously. In this review we discuss current understanding of the mechanisms by which p53 induces cell death and how this affects p53-...
When normal cells lose control over their division, differentiation, and the ability to undergo apoptosis, they become tumor cells. A tumor is the result of an abnormal proliferation of cells without differentiation and apoptosis. Tumor or neoplasm may be of two types: benign tumor and malignant ...