(57) I will disclose the methods and compositions to induce apoptosis and differentiation in cells overexpressing [summary] Notch protein. Cell fate determination function of Notch, it is specifically destroyed at a time when the cells are being differentiated, cells trigger apoptosis by this. It ...
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. The tumor suppressor p53 inhibits tumor growth primarily through its ability to induce apoptosis. Mutations in p53 occur in at least 50% of human tumors. W... VJN Bykov,N Issaeva,A Shilov,... ...
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 1994; 79: 329–339. Article CAS PubMed Google Scholar Chiou S-K, Rao L, White E . Bcl-2 blocks p53-dependent apoptosis. Mol Cell Biol 1994; 14: 2556–2563. ...
The latter are biologically active secondary plant metabolites, many of which modify cell proliferation and induce apoptosis in vitro. There is growing ... IT Johnson - 《Mutat Res》 被引量: 375发表: 2004年 History of the events leading to the formulation of the apoptosis concept. Histological...
Further investigation revealed that caspase cleavage of ROCK1 yields a constitutively active kinase fragment that is sufficient to induce membrane blebbing resembling that seen in apoptotic cells. In addition, the cleaved ROCK1 fragment appears to be important for disruption of nuclear integrity and the...
Mesenchymal stem/stromal cells (MSCs) have emerged as a promising tool in the field of regenerative medicine due to their unique therapeutic properties as they can differentiate into multiple cell types and exert paracrine effects. However, despite encouraging results obtained in preclinical studies, cl...
Evidence of functional ryanodine receptor involved in apoptosis of prostate ancer (LNCaP) cells Prostate, 43 (3) (2000), pp. 205-214 View in ScopusGoogle Scholar 10.1002/(sici)1097-0045(20000515)43:3<205::aid−pros6>3.0.co;2-m [16] S. Richard, D. Neveu, G. Carnac, P. Bodin, ...
What is the difference between how B Cells and various T Cells are produced and what is their associated function in the body's innate or adaptive immune system? What is the function of plasma cells? a. To produce plasma. b. To activate the T cells. c. To activate the B...
It was demonstrated that ERVs could be mobilized by treating cancer cells with DNA methyltransferase (DNMT) inhibitors resulting in the activation of the dsRNA sensors MDA5 and TLR316,17. This viral RNA sensing mechanism is often viewed as antiproliferative and in many cases to induce apoptosis ...
Apoptosis is a process of controlled cellular death whereby the activation of specific death-signaling pathways leads to deletion of cells from tissue. The... G Matute-Bello,TR Martin - 《Critical Care》 被引量: 346发表: 2003年 Mesenchymal stem cells in acute lung injury: are they ready for...