Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells. Sci Rep 2016;6:39123.Y. Lu, B. Wang, Q. Shi, X. Wang, D. Wang, and L. Zhu, "Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions...
Whole transcriptomic sequencing shows significant upregulation of the hypoxia‐inducible factor 1‐alpha (HIF‐1α) signaling pathway and associated downstream targets. Furthermore, Western blot analysis confirms elevated HIF‐1α protein in Cell Line A cells at later generation. These results suggest ...
Additionally, we performed transcriptome sequencing and found that hypoxia-inducible factor-1伪 (HIF-1伪) is involved in the above process and that CGRP can alleviate ARDS-related pathological damage, inflammation, and oxidative stress by inhibiting the HIF-1伪 pathway to regulate macrophage ...
an independent prognostic variable for poor overall survival. In conclusion, our data indicated that the TFRC-involved HIF-1 signaling pathway may play a crucial role in cervical cancer. We thank Juan Chen from CCN department of ZTE for her computer technology support. This work was supported by...
In order to further investigate the protein changes in PI3K/Akt/HIF-1α signaling pathway, we have employed the western blot assay to study the protein changes of p-Akt and HIF-1α in four different groups (Figure 2A and 2B). The expression of HIF-1α protein and p-Akt protein in OJ...
WDR72 activates the AKT/HIF-1α signaling pathway to enhance the stemness of lung cancer stem cells and promote the growth and metastasis of lung cancer. 1. Introduction Lung cancer has been of great concern worldwide due to its high incidence and high mortality rate [1]. Data released by...
hif1及ahr信号通路在a549细胞中相互作用的研究-study on interaction between hi f1 and ahr signaling pathway in a549 cells.docx,目录内蒙古医科大学学位论文原创性声明中文摘要···
Notably, HIF‑1α may also induce detrimental effects. The effects of HIF‑1 on ischemic outcomes may be dependent on the H‑I duration, animal age and species. Thus, further investigation of the PI3K/Akt signaling pathway may provide further insights of the potential targets for treating...
WU Xue-bing, AO Hua, LI Ming. Effects of Taohong Siwu Decoction on renal protection and ERK1/2/HIF-1α signaling pathway in rats with mesangial proliferative glomerulonephritis[J]. Journal of Clinical Nephrology, 2022, 22(2): 139-146. DOI: 10.3969/j.issn.1671-2390.2022.02.009 Effects...
Renal fibrosis is a common outcome of chronic kidney diseases and glycolysis drives the development of renal fibrosis in damaged kidneys. Ulinastatin (UTI) is a broad-spectrum protease inhibitor with anti-inflammatory and antioxidant properties with anti