signaling. HIF-1 exerts pleiotropic effects on both cancer and stromal cells. For example, HIF-α-dependent expression of VEGF-A and PDGF-B induces angiogenesis by promoting proliferation and migration of pericytes, endothelial and vascular smooth muscle cells. In cancer-associated fibroblasts (CAFs)...
英文名称 HIF-1 Signaling Pathway Compound Library 产品介绍 描述及优势 •443种HIF-1信号通路化合物的独特集合,用于高通量筛选(HTS)和高内涵筛选(HCS) •靶点包括HIF,HDAC,PI3K,MAPK,VHL等 •用于探索细胞氧感应的机制 •某些化合物已被FDA批准 •结构多样,具有药用活性且可渗透细胞 详细信息 配制...
Whole transcriptomic sequencing shows significant upregulation of the hypoxia‐inducible factor 1‐alpha (HIF‐1α) signaling pathway and associated downstream targets. Furthermore, Western blot analysis confirms elevated HIF‐1α protein in Cell Line A cells at later generation. These results suggest ...
Cell Signaling PathwayGastrointestinal TumorsEsophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and ...
www.nature.com/scientificreports OPEN received: 27 January 2016 accepted: 18 May 2016 Published: 06 June 2016 Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia Eun-Taex Oh1,2, Chan Woo Kim3, Soo Jung Kim1,...
(KEGG) pathway enrichment, which identified a transferrin receptor (TFRC)-involved HIF-1 signaling pathway (p < 0.05). Clinical data analysis showed that high TFRC expression in cervical cancers was associated with incrementally advanced stage, tumor status, and lymph nodes (allp-values <0.05...
HIF-1α/VEGF signaling pathway is thought to play a dual role following SCI. In one hand, VEGF was demonstrated to be correlated with angiogenesis (protecting vascular endothelial cells, increasing blood vessel density and improving regional blood flow), neurogenesis (antiapoptotic, neurotrophic, ...
Notably, HIF‑1α may also induce detrimental effects. The effects of HIF‑1 on ischemic outcomes may be dependent on the H‑I duration, animal age and species. Thus, further investigation of the PI3K/Akt signaling pathway may provide further insights of the potential targets for treating...
As a master regulator of hypoxia, hypoxia-inducible factor-1α (HIF-1α) has been reported to couple angiogenesis to osteogenesis. Our recent study has demonstrated that osteoblast growth is inhibited under hypoxia and that HIF-1α cooperates with Osterix (Osx) to inhibit Wnt pathway. However,...
HIF-1?? protein expression is elevated in many solid tumors, including those of the cervix and brain, where cells that are the greatest distance from blood vessels, and therefore the most hypoxic, express the highest levels of HIF-1??. Therapeutic blockade of the HIF-1 signaling pathway in...