Hypoxia Signaling Pathway Description Legend Hypoxia (low O2) is a pathophysiological condition resulting from the imbalance between cellular O2consumption and vascular perfusion. Hypoxia is a common feature of solid tumors associated with increased chemoradioresistance and poor patient prognosis. Metazoans ...
These results provide genetic evidence that the p38 MAPK signaling pathway is essential for HIF-1 activation. To further elucidate the direct targets of the ROS or the upstream regulators of p38 MAPK pathway a candidate approach was taken. Interestingly, the hypoxic activation of HIF-1 is ...
总的来说,我们认为常驻AMs中TLR2-hif1α介导的糖酵解的缺失可以改善过敏性气道炎症,抑制焦亡和氧化应激,因此常驻AMs中的TLR2-hif1α-糖酵解轴可能是AAI的一个新的治疗目标。 实验结果1 TLR2缺陷可改善OVA诱导的小鼠过敏性气道炎症 同型TLR2-/-小鼠通过PCR证实,这些小鼠没有TLR2蛋白表达。正如预期的那样,OVA...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
近10年来,有关HIF-1在细胞低氧应激时的信号转导通路,特别是HIF-1α介导的基因 转录调控的研究取得了巨大进展。 [关键词]低氧诱导因子1;低氧;反应元件;转录因子 [中图分类号]Q494[文献标志码]A[文章编号]1008-9292(2011)05-0559-08 HIF-1signalpathwayincellularresponsetohypoxia WANGPing-ping,KONGFan-ping...
p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway Moreover, data indicated enhanced HIF-1α expression by p55PIK-PI3K depended on its ability to activate NF-кB signaling pathways, especially to increase... G Wang,C Chen,R Yang,... - 《Angiogenesis》...
近 10 年来,有关 HIF- 1 在细胞低氧应激时的信号转导通路,特别是 HIF- 1α 介导的基因转录调控的研究取得了巨大进展。[关键词]低氧诱导因子 1;低氧;反应元件;转录因子Q 494[文献标志码][中图分类号]A[文章编号]1008- 9292( 2011)05- 0559- 08HIF- 1 signal pathway in cellular response to hypoxia...
Notably, HIF‑1α may also induce detrimental effects. The effects of HIF‑1 on ischemic outcomes may be dependent on the H‑I duration, animal age and species. Thus, further investigation of the PI3K/Akt signaling pathway may provide further insights of the potential targets for treating...
结果表明黄芪、丹参、三七共有9个共同通路(P<0.05),见图3,其中HIF-1 signaling pathway、PI3K-Akt signaling pathway、ras signaling pathway和rap1 signaling pathway与心肌缺血密切相关。由于HIF-1信号通路是有机体的低氧应激通路,在低氧下能迅...
(KEGG) pathway enrichment, which identified a transferrin receptor (TFRC)-involved HIF-1 signaling pathway (p < 0.05). Clinical data analysis showed that high TFRC expression in cervical cancers was associated with incrementally advanced stage, tumor status, and lymph nodes (allp-values <0.05...