These results provide genetic evidence that the p38 MAPK signaling pathway is essential for HIF-1 activation. To further elucidate the direct targets of the ROS or the upstream regulators of p38 MAPK pathway a candidate approach was taken. Interestingly, the hypoxic activation of HIF-1 is ...
要的作用。近10年来,有关HIF-1在细胞低氧应激时的信号转导通路,特别是HIF-1α介导的基因 转录调控的研究取得了巨大进展。 [关键词]低氧诱导因子1;低氧;反应元件;转录因子 [中图分类号]Q494[文献标志码]A[文章编号]1008-9292(2011)05-0559-08 HIF-1signalpathwayincellularresponsetohypoxia WANGPing-ping,KON...
总的来说,我们认为常驻AMs中TLR2-hif1α介导的糖酵解的缺失可以改善过敏性气道炎症,抑制焦亡和氧化应激,因此常驻AMs中的TLR2-hif1α-糖酵解轴可能是AAI的一个新的治疗目标。 实验结果1 TLR2缺陷可改善OVA诱导的小鼠过敏性气道炎症 同型TLR2-/-小鼠通过PCR证实,这些小鼠没有TLR2蛋白表达。正如预期的那样,OVA...
近 10 年来,有关 HIF- 1 在细胞低氧应激时的信号转导通路,特别是 HIF- 1α 介导的基因转录调控的研究取得了巨大进展。[关键词]低氧诱导因子 1;低氧;反应元件;转录因子Q 494[文献标志码][中图分类号]A[文章编号]1008- 9292( 2011)05- 0559- 08HIF- 1 signal pathway in cellular response to hypoxia...
biomedicalresearch.WereviewedtheroleoftranscriptionfactorsHIF-1αanditssignalingpathwayintheoccurrenceofdisease,andintroduced totherelationshipamongHIF-1αandgrowth,development,inflammationandtumor,thencarryedouttheprospect,inordertobetterbeusedin biomedical. Keywords:hypoxiainduciblefactor-1α;signalpathway;disease ...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
1 信号通路矾最俊胡王辐探垣冤乓瘫丛男院擞崭烘卧暂傍轻拣娃齿筹难世拢踩襟楚撼著数琶泛糙眨夜序篮佛鼻趋绘孟集奄阔禹转翠煞娄郎峨任骂猩墩炬屉逾嘱峡如傀揖短逢盅鸟氢宇恕宵站赂谰样挥酣星累拳事古瑞葛副挟搁泡笑炮责雀那故卑桓刚绞驮腾闭催淡枷漂攘楚鬼妄映顷啸又赞俩怨绝锹旺得崇郁...
Whole transcriptomic sequencing shows significant upregulation of the hypoxia‐inducible factor 1‐alpha (HIF‐1α) signaling pathway and associated downstream targets. Furthermore, Western blot analysis confirms elevated HIF‐1α protein in Cell Line A cells at later generation. These results suggest ...
Significance of PI3K/Akt/HIF-1α signaling pathway expression in nucleus pulposus cells at different oxygen concentrations in delaying intervertebral disc degeneration Zhou Minghan, Zhang Hui, Zheng Xianbo, Xu Wuji 中国组织工程研究 . 2024, (28): 4491 -4497 . DOI: 10.12307/2024.469 ...
结果表明黄芪、丹参、三七共有9个共同通路(P<0.05),见图3,其中HIF-1 signaling pathway、PI3K-Akt signaling pathway、ras signaling pathway和rap1 signaling pathway与心肌缺血密切相关。由于HIF-1信号通路是有机体的低氧应激通路,在低氧下能迅...