结果显示,与对照的TLR2-/-小鼠相比,EDHB处理的TLR2-/-小鼠对OVA的反应显示出严重的气道炎症和增加的焦亡、氧化应激和糖酵解,这与OVA挑战的WT小鼠的情况相当。这些结果显示,TLR2的缺失抑制了hif1α的表达,伴随着过敏性气道炎症的改善,而TLR2-/-小鼠通过EDHB上调hif1α,取消了TLR2缺失的这种保护作用。总之,作...
2. Ischia and hypoxia after CCH can not only activate HIF-1α signaling pathway, but also be a stimulating factor of NF-κB signal transduction pathway. These two signaling pathways have many intersections, and NF-κB activation provides positive feedback o...
目的:探究NF-κB/HIF-1α信号通路在慢性脑低灌注引起神经炎症过程中的作用及机制.方法:采用单侧颈总动脉永久性结扎(Unilateral Common Carotid Artery Occlusion,UCCAO)方法建立慢性脑低灌注小鼠模型,随机分为3大组,每组50只,分别为正常对照组,假手术组和UCCAO组,每大组按1 d,3 d,7 d,14 d,21 d分为5小组...
可以与上下游多种蛋白组成不同的信号通路,介导低氧信号,调控细胞产生一系列对缺氧的代偿反应, 在机体的生长发育及生理和病理过程中发挥重要作用,是生物医学研究的一个焦点.对转录因子 HIF-1α 及其信号通路在疾病发生 中的作用进行了综述,介绍了 HIF-1α 在动物生长发育,炎症和肿瘤中的研究概况,并进行了展望,以便...
HIF-1α可以与上下游多种蛋白组成不同的信号通路,介导低氧信号,调控细胞产生一系列对缺氧的代偿反应,在机体的生长发育及生理和病理过程中发挥重要作用,是生物医学研究的一个焦点。对转录因子 HIF-1α及其信号通路在疾病发生中的作用进行了综述,介绍了 HIF-1α在动物生长发育、炎症和肿瘤中的研究概况,并进行了展望,...
HO是一种在非骨骼组织中异常骨形成的状况,通常在组织受伤后由炎症引发。尽管已知多种细胞和分子途径参与异位骨形成,但创伤性HO的病理生理机制仍不清楚。我们之前的研究表明HIF-1α是HO的一个强效刺激因子,但其在HO进展中的分子机制尚不完全清楚,限制了治疗进展。在本研究中,我们使用单细胞和空间转录分析以及BT小鼠...
Under hypoxia conditions, HIF-1α signaling is activated and responsible for cell biology associated with metabolism, inflammation, vascular homeostasis and tumorigenesis. Activation of HIF-1α signaling has been observed in a series of cancers including gastric cancer. Moreover, a variety of oncogene...
However, molecular mechanisms for inhibitory effects of HIF-1α on Wnt pathway are not well understood. In this study, our quantitative RT-PCR results revealed that the expression of a Wnt antagonist Sclerostin (Sost) was upregulated in osteoblasts during hypoxia while HIF-1α was upregulated....
www.nature.com/scientificreports OPEN received: 27 January 2016 accepted: 18 May 2016 Published: 06 June 2016 Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia Eun-Taex Oh1,2, Chan Woo Kim3, Soo Jung Kim1,...
Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.