We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
The mRNA levels of aging-related genes, inflammatory aging-related secretory phenotypes and core targets in HIF-1 signaling pathway were detected by qRT-PCR. Results The results showed that 95 compounds were identified from Renshen Guben Pills, 12 core targets were identified through network ...
内容提示: 令其他研究| QITAYAN 』 U运动干预抗癌机制: HIF - la 信号通路调控作用的研究进展The Mechanism of Anticancer Action of Exercise Intervention : the Research Progress on the Regulatory Role of HIF - la Signaling Pathway孔健达 , 穆玉晶 , 朱磊 Kong Jianda , Mu Yujing,Zhu Lei摘 要:近年...
HIF-1α可以与上下游多种蛋白组成不同的信号通路,介导低氧信号,调控细胞产生一系列对缺氧的代偿反应, 在机体的生长发育及生理和病理过程中发挥重要作用,是生物医学研究的一个焦点。对转录因子HIF-1α及其信号通路在疾病发生 中的作用进行了综述,介绍了HIF-1α在动物生长发育、炎症和肿瘤中的研究概况,并进行了展望,...
【关键词】 间充质干细胞动员;DMOG;缺氧诱导因子一1;基质细胞衍生因子一let;血管内皮生长因子 【中图分类号】R332 【文献标识码】A 【文章编号】1671.7856(2015)01-0009-06 doi:10.3969.j.issn.1671.7856.2015.O01.002 MechanismofHIF一1signalingpathwayinmediating MSCsmobilizationwithDMoG HUShao-jun’,YUQin’,...
enhanced the expressions of Bax and cleaved caspase-3, and decreased Bcl-2 expression in SMMC-7721 cells (P<0.05). Conclusions Shikonin induces apoptosis of SMMC-7721 cells possibly by inhibiting aerobic glycolysis through the PKM2/PHD3/HIF-1α signaling pathway to cause energy supply dysfunction...
应激的 HIF-1 信号通路王苹苹,孔繁平,陈学群,杜继曾( 浙江大学医学院 基础医学系,浙江 杭州 310058)综述[摘要]低氧诱导因子( hypoxia inducible factor, HIF) 由 HIF- 1α 和 HIF- 1β 两个亚基组成, 在低氧下其能激活多种靶基因的转录,在细胞、组织生长发育和生理应激, 以及某些病理过程中具有重要的作用...
HIF-1 related signaling pathway and its role in autoimmune diseases 在线阅读 下载PDF 引用 收藏 分享 摘要 自身免疫性疾病(AID)是一类由自身抗原引起自身组织损伤的疾病。目前治疗AID仍以对症治疗和控制病情进展的药物为主,缺乏有效治疗措施,从而造成其致死率较高、治愈率较低的现状。因此对AID发病机制的详细...
Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression 组蛋白去甲基化酶JMJD2D通过多种机制激活HIF1信号通路,促进结直肠癌糖酵解和进展 Oncogene(IF=7.971),2020 Nov;39(47):7076-7091. ...
结果表明黄芪、丹参、三七共有9个共同通路(P<0.05),见图3,其中HIF-1 signaling pathway、PI3K-Akt signaling pathway、ras signaling pathway和rap1 signaling pathway与心肌缺血密切相关。由于HIF-1信号通路是有机体的低氧应激通路,在低氧下能迅...