生理条件下,HIF-1α在月经,子宫内膜蜕膜化,和调节脱膜组织免疫功能等过程中发挥重要作用,参与维持子宫内膜强大的再生能力。然而,异常的HIF-1α水平会加剧各种子宫内膜疾病的发生与发展。深入探究HIF-1α参与子宫内膜疾病的机制,并探索以HIF-1α为中心的改善子宫内膜疾病的治疗策略具有重要的临床意义。这里,作者梳理了...
biomedicalresearch.WereviewedtheroleoftranscriptionfactorsHIF-1αanditssignalingpathwayintheoccurrenceofdisease,andintroduced totherelationshipamongHIF-1αandgrowth,development,inflammationandtumor,thencarryedouttheprospect,inordertobetterbeusedin biomedical. Keywords:hypoxiainduciblefactor-1α;signalpathway;disease ...
Fig. 1 Hypoxia signaling pathways crosstalk with Notch and Myc pathways 著差异发生在 PHD-2 和 HIF-2α 基因上,或者 是靠近这些基因的位置。由此推测,藏族人的 PHD-2 和HIF-2α 受到青藏高原物理环境的选 择压力而产生了突变,赋予藏人适应青藏高原 的能力。最直接的表现就是藏族人对慢性高原 病有强的抵...
内容提示: 令其他研究| QITAYAN 』 U运动干预抗癌机制: HIF - la 信号通路调控作用的研究进展The Mechanism of Anticancer Action of Exercise Intervention : the Research Progress on the Regulatory Role of HIF - la Signaling Pathway孔健达 , 穆玉晶 , 朱磊 Kong Jianda , Mu Yujing,Zhu Lei摘 要:近年...
需要金币:*** 金币(10金币=人民币1元) _低氧细胞应激HIF-1信号通路.pdf 关闭预览 想预览更多内容,点击免费在线预览全文 免费在线预览全文 _低氧细胞应激HIF-1信号通路 容娟谚梨基燥遮括狂涪酷秉囊外下糟雕惰箱揭隘臭捏催启晰渔瞒饶航变柱贝台吝歼泥锥券罗捆吊屈心婪镀陇媒府医钉隔谦恋偷妓在狱钎睛...
Regulating the HIF-1α-related signaling pathway is expected to be a new strategy to maintain organ functions during cold storage of isolated organs. 【 Keywords】 hypoxia-inducible factor 1α; cold storage; organ transplantation; metabolism; oxidative stress Conflicts of Interest: The authors ...
(AAI), yet the underlying mechanism remains elusive. Here, in a murine AAI model, TLR2−/− mice showed decreased airway inflammation, pyroptosis and oxidative stress. RNA-sequencing revealed that allergen-induced hif1 signaling pathway and glycolysis were significantly downregulated when TLR2 was...
enhanced the expressions of Bax and cleaved caspase-3, and decreased Bcl-2 expression in SMMC-7721 cells (P<0.05). Conclusions Shikonin induces apoptosis of SMMC-7721 cells possibly by inhibiting aerobic glycolysis through the PKM2/PHD3/HIF-1α signaling pathway to cause energy supply dysfunction...
The mRNA levels of aging-related genes, inflammatory aging-related secretory phenotypes and core targets in HIF-1 signaling pathway were detected by qRT-PCR. Results The results showed that 95 compounds were identified from Renshen Guben Pills, 12 core targets were identified through network ...