近期，一项发表于Sci Rep的研究The role of lipids in promoting hair growth through HIF-1 signaling pathway为脱发治疗领域带来了令人振奋的新发现——脂质在促进头发生长中发挥着关键作用，且这一过程与HIF-1信号通路密切相关。细胞的代谢平衡对维持正常生理功能至关重要，其中脂质
该研究表明,脂质能够触发 DPCs 的毛发诱导能力,延长毛囊类器官的毛干样结构。脂质处理通过 HIF-1α 介导激活毛发相关基因,这可能成为治疗脱发的相关靶点,脂质补充也可应用于体外制备带毛干的毛囊用于毛发移植。 此前研究虽已发现脂质代谢异常与多种疾病有关,且有研究提示脂质对毛囊再生和毛发周期有重要作用,但脂质在...
卡格列净通过SIRT6/HIF-1α信号通路改善高盐诱导的主动脉硬化和早衰现象 《Molecular and Cellular Biochemistry》:Canagliflozin improves high-salt-induced aortic arteriosclerosis and premature aging in dahl salt-sensitive rats through the SIRT6/HIF-1 α signaling pathway 编辑推荐: 高血压及其并发症严重威胁人...
//引用本文刘祎曼, 贾慧雨, 冯文帅, 等. 中医药调控HIF-1α信号通路治疗心肌缺血再灌注损伤的研究进展. 天津中医药, 2025, 42(4): 519-525.LIU Yiman, JIA Huiyu, FENG Wenshuai, et al. Research progress of HIF-1α sign...
HIF-1 signaling pathway Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a constitutively-expressed HIF-1beta subunit. Under normoxia, HIF-1 alpha ...
biomedicalresearch.WereviewedtheroleoftranscriptionfactorsHIF-1αanditssignalingpathwayintheoccurrenceofdisease,andintroduced totherelationshipamongHIF-1αandgrowth,development,inflammationandtumor,thencarryedouttheprospect,inordertobetterbeusedin biomedical. Keywords:hypoxiainduciblefactor-1α;signalpathway;disease ...
要的作用。近10年来,有关HIF-1在细胞低氧应激时的信号转导通路,特别是HIF-1α介导的基因 转录调控的研究取得了巨大进展。 [关键词]低氧诱导因子1;低氧;反应元件;转录因子 [中图分类号]Q494[文献标志码]A[文章编号]1008-9292(2011)05-0559-08 HIF-1signalpathwayincellularresponsetohypoxia WANGPing-ping,KON...
Regulating the HIF-1α-related signaling pathway is expected to be a new strategy to maintain organ functions during cold storage of isolated organs. 【 Keywords】 hypoxia-inducible factor 1α; cold storage; organ transplantation; metabolism; oxidative stress Conflicts of Interest: The authors ...
Conclusions Shikonin induces apoptosis of SMMC-7721 cells possibly by inhibiting aerobic glycolysis through the PKM2/PHD3/HIF-1α signaling pathway to cause energy supply dysfunction in the cells. Key words: hepatocellular carcinoma; shikonin; pyruvate kinase M2; prolyl hydroxylase 3; hypoxia-inducible...