We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
【关键词】 间充质干细胞动员;DMOG;缺氧诱导因子一1;基质细胞衍生因子一let;血管内皮生长因子 【中图分类号】R332 【文献标识码】A 【文章编号】1671.7856(2015)01-0009-06 doi:10.3969.j.issn.1671.7856.2015.O01.002 MechanismofHIF一1signalingpathwayinmediating MSCsmobilizationwithDMoG HUShao-jun’,YUQin’,...
1 promotes the expression of hundreds of genes involved in cell autonomous and non-autonomous adaptations to hypoxia. Examples of genes and their functions are found in the diagram. HIF-α can be upregulated at the protein level via mTOR or at the mRNA level via STAT3 and NF-κB signaling....
英文名称 HIF-1 Signaling Pathway Compound Library 产品介绍 描述及优势 •443种HIF-1信号通路化合物的独特集合,用于高通量筛选(HTS)和高内涵筛选(HCS) •靶点包括HIF,HDAC,PI3K,MAPK,VHL等 •用于探索细胞氧感应的机制 •某些化合物已被FDA批准 •结构多样,具有药用活性且可渗透细胞 详细信息 配制...
(AAI), yet the underlying mechanism remains elusive. Here, in a murine AAI model, TLR2−/− mice showed decreased airway inflammation, pyroptosis and oxidative stress. RNA-sequencing revealed that allergen-induced hif1 signaling pathway and glycolysis were significantly downregulated when TLR2 was...
HIF-1α可以与上下游多种蛋白组成不同的信号通路,介导低氧信号,调控细胞产生一系列对缺氧的代偿反应, 在机体的生长发育及生理和病理过程中发挥重要作用,是生物医学研究的一个焦点。对转录因子HIF-1α及其信号通路在疾病发生 中的作用进行了综述,介绍了HIF-1α在动物生长发育、炎症和肿瘤中的研究概况,并进行了展望,...
the research on signaling pathways of HIF- 1 in response to cell hypoxiastress, especially on HIF- 1α-mediated gene transcription has made great progress.[Key words]Hypoxia-inducible factor 1; Hypoxia; Response elements; Transcription factors[J Zhejiang Univ ( Medical Sci) , 2011,40( 5) :55...
the Research Progress on the Regulatory Role of HIF - la Signaling Pathway孔健达 , 穆玉晶 , 朱磊 Kong Jianda , Mu Yujing,Zhu Lei摘 要:近年来 , 有大量研究表明 HIF-la 可作为癌症治疗的一个靶点 , 而运动抗癌亦被广泛认可 , 其作用 机制与 HIF-la 相关信号通路密不可分 , 但其具体机制研究尚...
[Key words ] Hypoxia inducible factor⁃1;Cell signaling pathway;Autoimmune disease 1 HIF⁃1的结构㊁表达调控及生物学特性 1.1 HIF⁃1的结构 HIF⁃1(Hypoxia inducible factor⁃1,HIF⁃1)即缺氧诱导因子⁃1,是由Semenza 等[1]在1992年研究促红细胞生成素基因表达的影响因素时,在缺氧诱导的...
enhanced the expressions of Bax and cleaved caspase-3, and decreased Bcl-2 expression in SMMC-7721 cells (P<0.05). Conclusions Shikonin induces apoptosis of SMMC-7721 cells possibly by inhibiting aerobic glycolysis through the PKM2/PHD3/HIF-1α signaling pathway to cause energy supply dysfunction...