We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
结果表明黄芪、丹参、三七共有9个共同通路(P<0.05),见图3,其中HIF-1 signaling pathway、PI3K-Akt signaling pathway、ras signaling pathway和rap1 signaling pathway与心肌缺血密切相关。由于HIF-1信号通路是有机体的低氧应激通路,在低氧下能迅...
【关键词】间充质干细胞动员;DMOG;缺氧诱导因子-1α;基质细胞衍生因子-lα;血管内皮生长因子【中图分类号】R332【文献标识码】A【文章编号】1671-7856(2015)01-0009-06doi:10.3969.j.issn.1671.7856.2015.001.002MechanismofHIF-1signalingpathwayinmediatingMSCsmobilizationwithDMOGHUShao-jun1,YUQin1,LIULi-zhen2,...
可被控制。最近的研究发现,低氧诱导因子.1Q(HIF.1Q)是一种主要在缺氧条件 下表达的转录因子,它与增强脊髓组织细胞的耐受低氧能力,促进脊髓新生血管 的形成密切相关【31。本研究旨在通过对HIF.1Q在实验性继发性脊髓损伤中的表达 机制及其特点进行研究,探讨HIF.1Q在脊髓修复中的意义,为临床继发性脊髓损 ...
the research on signaling pathways of HIF- 1 in response to cell hypoxiastress, especially on HIF- 1α-mediated gene transcription has made great progress.[Key words]Hypoxia-inducible factor 1; Hypoxia; Response elements; Transcription factors[J Zhejiang Univ ( Medical Sci) , 2011,40( 5) :55...
Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression 组蛋白去甲基化酶JMJD2D通过多种机制激活HIF1信号通路,促进结直肠癌糖酵解和进展 Oncogene(IF=7.971),2020 Nov;39(47):7076-7091. ...
4 Effect of carvacrol on expressions of HIF-1α/SLC7A11 signaling pathway related proteins in HSC-T6 cells ( x s , n = 3) 胞质 HIF-1α β-actin 核 HIF-1α histone H3 总 HIF-1α SLC7A11 β-actin 1.20×105 4.20×104 1.20×105 1.50×104 1.20×105 5.50×104 4.20×104 香芹...
enhanced the expressions of Bax and cleaved caspase-3, and decreased Bcl-2 expression in SMMC-7721 cells (P<0.05). Conclusions Shikonin induces apoptosis of SMMC-7721 cells possibly by inhibiting aerobic glycolysis through the PKM2/PHD3/HIF-1α signaling pathway to cause energy supply dysfunction...
[Key words ] Hypoxia inducible factor⁃1;Cell signaling pathway;Autoimmune disease 1 HIF⁃1的结构㊁表达调控及生物学特性 1.1 HIF⁃1的结构 HIF⁃1(Hypoxia inducible factor⁃1,HIF⁃1)即缺氧诱导因子⁃1,是由Semenza 等[1]在1992年研究促红细胞生成素基因表达的影响因素时,在缺氧诱导的...