signaling. HIF-1 exerts pleiotropic effects on both cancer and stromal cells. For example, HIF-α-dependent expression of VEGF-A and PDGF-B induces angiogenesis by promoting proliferation and migration of pericytes, endothelial and vascular smooth muscle cells. In cancer-associated fibroblasts (CAFs)...
Gel shift assay showed that HIF-1 bound to the promoter sequence of Sost directly. These findings support our hypothesis that HIF-1α activates Sost expression. This study provides a novel molecular mechanism through which HIF-1α inhibits Wnt signaling in osteoblasts. 展开 ...
Activation of HIF-1α signaling has been observed in a series of cancers including gastric cancer. Moreover, a variety of oncogene products may be induced by HIF-1α expression. Pharmacologic manipulation of HIF-1α may provide a novel therapeutic approach to gastric cancer. In this review, ...
HIF-1信号通路化合物库 目录号:L6100 441种HIF-1信号通路化合物的集合,可用于细胞氧感知相关研究。 规格 预溶于DMSO或水 100uL/well 询价获取超大折扣 全国免费电话:400-668-6834 | Email:info@selleck.cn 您可以选择: 特定分子选择 规格 分子所置板上位置...
Expression and contribution of the HIF-1α/VEGF signaling pathway to luteal development and function in pregnant rats. Mol Med Rep. 2015;12(5):7153-9... Lixiang,Wu,Zhenghong,... - 《Molecular Medicine Reports》 被引量: 6发表: 2015年 Expression and tissue concentration of vascular endothelia...
(KEGG) pathway enrichment, which identified a transferrin receptor (TFRC)-involved HIF-1 signaling pathway (p < 0.05). Clinical data analysis showed that high TFRC expression in cervical cancers was associated with incrementally advanced stage, tumor status, and lymph nodes (allp-values <0.05...
In this study, we selected the SD rats and H9C2 cell line to investigate the protective mechanism of HIF-1α/BNIP3 signaling pathway associated autophagy under I/R and OGD/R. In the present study, we used OGD/R treatment to mimic the process of acute myocardial infarction in H9C2 cells ...
www.nature.com/scientificreports OPEN received: 27 January 2016 accepted: 18 May 2016 Published: 06 June 2016 Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia Eun-Taex Oh1,2, Chan Woo Kim3, Soo Jung Kim1,...
Malaria interaction with cytokine and cytokine receptor hematopoietic cell lineage antigen processing and presentation p53 signaling pathway pyrimidine metabolism African trypanosomiasis 0.050 0.100 Gene ratio 0.05 0.10 0.15 Gene ratio A-GSE68870 数据集 DEGs 的火山图;B-GO 功能富集分析;C-KEGG 通路富集分析...
biology Article Hypoxia Affects HIF-1/LDH-A Signaling Pathway by Methylation Modification and Transcriptional Regulation in Japanese Flounder (Paralichthys olivaceus) Binghua Liu 1, Haishen Wen 1, Jun Yang 1, Xiaohui Li 1, Guangling Li 1, Jingru Zhang 1, Shuxian Wu 1, Ian AE Butts 2 and ...