We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
HIF-1α可以与上下游多种蛋白组成不同的信号通路,介导低氧信号,调控细胞产生一系列对缺氧的代偿反应, 在机体的生长发育及生理和病理过程中发挥重要作用,是生物医学研究的一个焦点。对转录因子HIF-1α及其信号通路在疾病发生 中的作用进行了综述,介绍了HIF-1α在动物生长发育、炎症和肿瘤中的研究概况,并进行了展望,...
【关键词】 间充质干细胞动员;DMOG;缺氧诱导因子一1;基质细胞衍生因子一let;血管内皮生长因子 【中图分类号】R332 【文献标识码】A 【文章编号】1671.7856(2015)01-0009-06 doi:10.3969.j.issn.1671.7856.2015.O01.002 MechanismofHIF一1signalingpathwayinmediating MSCsmobilizationwithDMoG HUShao-jun’,YUQin’,...
应激的 HIF-1 信号通路王苹苹,孔繁平,陈学群,杜继曾( 浙江大学医学院 基础医学系,浙江 杭州 310058)综述[摘要]低氧诱导因子( hypoxia inducible factor, HIF) 由 HIF- 1α 和 HIF- 1β 两个亚基组成, 在低氧下其能激活多种靶基因的转录,在细胞、组织生长发育和生理应激, 以及某些病理过程中具有重要的作用...
The mRNA levels of aging-related genes, inflammatory aging-related secretory phenotypes and core targets in HIF-1 signaling pathway were detected by qRT-PCR. Results The results showed that 95 compounds were identified from Renshen Guben Pills, 12 core targets were identified through network ...
谢文强，卢涣滋，林冬佳，杨利洒，王智∗ （中山大学附属口腔医院㊃中山大学光华口腔医学院，广东省口腔医学重点实验室，广东广州５１００５５）［摘要］㊀目的：探究口腔鳞状细胞癌（ＯＳＣＣ）肿瘤微环境中活性氧（ＲＯＳ）对肿瘤浸润Ｔ淋巴细胞分化的作用㊂方法：流式细胞术分析ＯＳＣＣ肿瘤组织和远端正常...
结果表明黄芪、丹参、三七共有9个共同通路(P<0.05),见图3,其中HIF-1 signaling pathway、PI3K-Akt signaling pathway、ras signaling pathway和rap1 signaling pathway与心肌缺血密切相关。由于HIF-1信号通路是有机体的低氧应激通路,在低氧下能迅...
10. Lv C, Li Z, Wang Q, Wang Y, Zhao X, Zhang Y. miRNA-150_R-1 mediates the HIF-1/ErbB signaling pathway to regulate the adhesion of endometrial epithelial cells in cows experiencing retained placenta. Front Vet Sci 2022, 9: 1037880. ...
www.nature.com/scientificreports OPEN received: 27 January 2016 accepted: 18 May 2016 Published: 06 June 2016 Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia Eun-Taex Oh1,2, Chan Woo Kim3, Soo Jung Kim1,...