JMJD2D通过三种不同的机制激活HIF1信号通路:JMJD2D协同转录因子SOX9增强mTOR表达,进而促进HIF1的mrna翻译;JMJD2D协同转录因子c-Fos增强HIF1的转录;JMJD2D与HIF1模型相互作用并协同增强糖酵解基因的表达。去甲基化酶缺陷突变体JMJD2D不能诱导mTOR、HIF1卵黄酮、HIF1基因和糖酵解基因的表达,提示JMJD2D的去甲基化酶活...
Hypoxia Signaling Pathway 缺氧信号通路 动物细胞对氧气的感知和反应是一个非常重要的过程,而缺氧(Hypoxia)是指一种细胞氧气消耗和血管氧气输送失衡,所数的细胞内氧气含量和压力低于正常水平的生理情况,其产生的原因包括低氧血症,氧输送受损和细胞氧吸收受损等等。无论是全身性还是细胞水平上的缺氧,机体都可以利用多种...
With comprehensive understanding of temporal and spatial of HIF-1α/VEGF signaling pathway, development of therapeutic strategies to promote new vessel growth while minimize the deleterious effects of VEGF-induced microvascular permeability, and thereby improve neurologic function, seems to be feasible and...
Notably, HIF‑1α may also induce detrimental effects. The effects of HIF‑1 on ischemic outcomes may be dependent on the H‑I duration, animal age and species. Thus, further investigation of the PI3K/Akt signaling pathway may provide further insights of the potential targets for treating...
This pathway is important in osteoblasts for differentiation, proliferation and the synthesis bone matrix, whereas osteocytes appear to use the Wnt/尾-... LF Bonewald,ML Johnson - 《Bone》 被引量: 1453发表: 2008年 BMP signaling negatively regulates bone mass through sclerostin by inhibiting the...
HIF-1α-i NOS signaling pathway;Rosuvastatin;Ischemic post-treatment;Diabetic;Ischemia-reperfusion injury; DOI: 10.13241/j.cnki.pmb.2022.04.003 Series: (E) Medicine & Public Health Subject: Surgery Classification Code: R614 Mobile Reading
In this study, we selected the SD rats and H9C2 cell line to investigate the protective mechanism of HIF-1α/BNIP3 signaling pathway associated autophagy under I/R and OGD/R. In the present study, we used OGD/R treatment to mimic the process of acute myocardial infarction in H9C2 cells ...
(KEGG) pathway enrichment, which identified a transferrin receptor (TFRC)-involved HIF-1 signaling pathway (p < 0.05). Clinical data analysis showed that high TFRC expression in cervical cancers was associated with incrementally advanced stage, tumor status, and lymph nodes (allp-values <0.05...
内容提示: 令其他研究| QITAYAN 』 U运动干预抗癌机制: HIF - la 信号通路调控作用的研究进展The Mechanism of Anticancer Action of Exercise Intervention : the Research Progress on the Regulatory Role of HIF - la Signaling Pathway孔健达 , 穆玉晶 , 朱磊 Kong Jianda , Mu Yujing,Zhu Lei摘 要:近年...
expression and contribution of the hif-1α/vegf signaling pathway to luteal development and function in pregnant rats Expression and contribution of the HIF-1α/VEGF signaling pathway to luteal development and function in pregnant rats. Mol Med Rep. 2015;12(5):7153-9... L Wu,Z Zhang,X Pan...