英文名称 HIF-1 Signaling Pathway Compound Library 产品介绍 描述及优势 •443种HIF-1信号通路化合物的独特集合,用于高通量筛选(HTS)和高内涵筛选(HCS) •靶点包括HIF,HDAC,PI3K,MAPK,VHL等 •用于探索细胞氧感应的机制 •某些化合物已被FDA批准 •结构多样,具有药用活性且可渗透细胞 详细信息 配制...
443种HIF-1信号通路化合物的集合,可用于细胞氧感知相关研究。 规格 预溶于DMSO或水 100uL/well 询价获取超大折扣 全国免费电话:400-668-6834 | Email:info@selleck.cn 您可以选择: 特定分子选择 规格 分子所置板上位置 粉末或DMSO溶液 客户使用该化合物库发表的文献286篇: ...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
基于前期收集的活性成分潜在靶点,利用DAVID数据库进行单味药材的KEGG通路富集分析, 见表2~5。结果表明黄芪、丹参、三七共有9个共同通路(P<0.05),见图3,其中HIF-1 signaling pathway、PI3K-Akt signaling pathway、ras signaling pathway和rap1 ...
Whole transcriptomic sequencing shows significant upregulation of the hypoxia‐inducible factor 1‐alpha (HIF‐1α) signaling pathway and associated downstream targets. Furthermore, Western blot analysis confirms elevated HIF‐1α protein in Cell Line A cells at later generation. These results suggest ...
【关键词】间充质干细胞动员;DMOG;缺氧诱导因子-1α;基质细胞衍生因子-lα;血管内皮生长因子【中图分类号】R332【文献标识码】A【文章编号】1671-7856(2015)01-0009-06doi:10.3969.j.issn.1671.7856.2015.001.002MechanismofHIF-1signalingpathwayinmediatingMSCsmobilizationwithDMOGHUShao-jun1,YUQin1,LIULi-zhen2,...
signaling. HIF-1 exerts pleiotropic effects on both cancer and stromal cells. For example, HIF-α-dependent expression of VEGF-A and PDGF-B induces angiogenesis by promoting proliferation and migration of pericytes, endothelial and vascular smooth muscle cells. In cancer-associated fibroblasts (CAFs)...
[关键词]低氧诱导因子1;低氧;反应元件;转录因子[中图分类号]Q494[文献标志码]A[文章编号]1008-9292(2011)05-0559-08HIF-1signalpathwayincellularresponsetohypoxiaWANGPing-ping,KONGFan-ping,CHENXue-qun,DUJi-zeng(DepartmentofBasicMedicalSciences,ZhejiangUniversitySchoolofMedicine,Hangzhou310058,China)[Abstract...
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These results provide genetic evidence that the p38 MAPK signaling pathway is essential for HIF-1 activation. To further elucidate the direct targets of the ROS or the upstream regulators of p38 MAPK pathway a candidate approach was taken. Interestingly, the hypoxic activation of HIF-1 is ...