443种HIF-1信号通路化合物的集合,可用于细胞氧感知相关研究。 规格 预溶于DMSO或水 100uL/well 询价获取超大折扣 全国免费电话:400-668-6834 | Email:info@selleck.cn 您可以选择: 特定分子选择 规格 分子所置板上位置 粉末或DMSO溶液 客户使用该化合物库发表的文献286篇: ...
结果表明黄芪、丹参、三七共有9个共同通路(P<0.05),见图3,其中HIF-1 signaling pathway、PI3K-Akt signaling pathway、ras signaling pathway和rap1 signaling pathway与心肌缺血密切相关。由于HIF-1信号通路是有机体的低氧应激通路,在低氧下能迅...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
However, tumor cells survive in these severe conditions by adapting to hypoxic stress through the induction of hypoxia-inducible factor 1 (HIF-1) signaling. HIF-1 activation is responsible for the expression of numerous HIF-1 target genes, which are related to cell survival, proliferation, ...
[Abstract]HIF- 1 is composed of HIF- 1α and HIF- 1β subunits. It promotes target genes transcriptionunder hypoxia and plays essential roles in cell development, physiological adaptations, and pathologicalprocesses. In the past 10 years, the research on signaling pathways of HIF- 1 in ...
signaling. HIF-1 exerts pleiotropic effects on both cancer and stromal cells. For example, HIF-α-dependent expression of VEGF-A and PDGF-B induces angiogenesis by promoting proliferation and migration of pericytes, endothelial and vascular smooth muscle cells. In cancer-associated fibroblasts (CAFs)...
Vol.:(0123456789)13JCompPhysiolBDOI10.1007/s00360-017-1083-8ORIGINALPAPERIdenti cationo HIF-1signalingpathwayin PelteobagrusvachelliusingRNA-Seq:e ectso acutehypoxiaand reoxygenationon oxygensensors,respiratorymetabolism,and hematologyindicesGuosong Zhang1,2 ·Cheng Zhao1,2 ·Qintao Wang1 ·Yichun Gu...
Whole transcriptomic sequencing shows significant upregulation of the hypoxia‐inducible factor 1‐alpha (HIF‐1α) signaling pathway and associated downstream targets. Furthermore, Western blot analysis confirms elevated HIF‐1α protein in Cell Line A cells at later generation. These results suggest ...
[Abstract]HIF-1iscomposedofHIF-1αandHIF-1βsubunits.Itpromotestargetgenestranscriptionunderhypoxiaandplaysessentialrolesincelldevelopment,physiologicaladaptations,andpathologicalprocesses.Inthepast10years,theresearchonsignalingpathwaysofHIF-1inresponsetocellhypoxiastress,especiallyonHIF-1α-mediatedgenetranscriptionhas...
【关键词】 肺纤维化 ; 博来霉素; 缺氧诱导因子 1 0【; 表面活性物质 C The Role of PD K/Akt/HIF-l仅Signaling Pathway in Bleomycin·Induced Pulmonary Fibrosis in Mice Ma Aiping ,Gao Yunzhou,Lan Wenbin,Qu Yuejin,Liu Qun. Department ofRespiratory Medicine,The First Aff iliated Hospital o f ...