signaling. HIF-1 exerts pleiotropic effects on both cancer and stromal cells. For example, HIF-α-dependent expression of VEGF-A and PDGF-B induces angiogenesis by promoting proliferation and migration of pericytes, endothelial and vascular smooth muscle cells. In cancer-associated fibroblasts (CAFs)...
[Abstract]HIF- 1 is composed of HIF- 1α and HIF- 1β subunits. It promotes target genes transcriptionunder hypoxia and plays essential roles in cell development, physiological adaptations, and pathologicalprocesses. In the past 10 years, the research on signaling pathways of HIF- 1 in ...
These processes could alter mitochondrial morphology, number, as well as distribution, to regulate complicated cellular signaling processes like metabolism. Meanwhile, they also could modulate cell proliferation and apoptosis. The initiation and progression of several diseases, such as tumors, NDs, ...
5 Zhang, J. et al. ROS and ROS-Mediated Cellular Signaling. Oxidative medicine and cellular longevity2016, 4350965, doi:10.1155/2016/4350965 (2016).
(AAI), yet the underlying mechanism remains elusive. Here, in a murine AAI model, TLR2−/− mice showed decreased airway inflammation, pyroptosis and oxidative stress. RNA-sequencing revealed that allergen-induced hif1 signaling pathway and glycolysis were significantly downregulated when TLR2 was...
需要金币:*** 金币(10金币=人民币1元) _低氧细胞应激HIF-1信号通路.pdf 关闭预览 想预览更多内容,点击免费在线预览全文 免费在线预览全文 _低氧细胞应激HIF-1信号通路 容娟谚梨基燥遮括狂涪酷秉囊外下糟雕惰箱揭隘臭捏催启晰渔瞒饶航变柱贝台吝歼泥锥券罗捆吊屈心婪镀陇媒府医钉隔谦恋偷妓在狱钎睛...
Fig. 1 Hypoxia signaling pathways crosstalk with Notch and Myc pathways 著差异发生在 PHD-2 和 HIF-2α 基因上,或者 是靠近这些基因的位置。由此推测,藏族人的 PHD-2 和HIF-2α 受到青藏高原物理环境的选 择压力而产生了突变,赋予藏人适应青藏高原 的能力。最直接的表现就是藏族人对慢性高原 病有强的抵...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
题目:EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells 译名:EGFR-HIF1α信号正向调节产生IL-9的T辅助细胞的分化 期刊:Nature Communications IF:12.120 发表时间:2021年6月1日 通讯作...
Reciprocal Regulation between the Circadian Clock and Hypoxia Signaling at the Genome Level in Mammals.Nature chemical biology2017;25(1): 73-85. 5.Adamovich Y, Ladeuix B, Golik M, Koeners MP, Asher G. Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1alpha.Cell metabolism2017;25(1...