Torres-Capelli, M. et al. Role Of Hif2alpha Oxygen Sensing Pathway In Bronchial Epithelial ClubCell Proliferation. Scientific reports 6, 25357, https://doi.org/10.1038/srep25357 (2016).Torres-Capelli, M.; Marsboom, G.; Li, Q.O.; Tello, D.; Rodriguez, F.M.; Alonso, T.; Sanchez-...
Rouault-Pierre K等研究发现无论是常氧还是低氧,HIF-2α的敲除对于抑制造血祖细胞(HPCs)分化形成红系集落较HIF-1α敲除更为显著,但这可能与shHIF-1α细胞中HIF-2α水平代偿性升高有关,进一步通过异种移植模型发现shHIF-2α HPCs在小鼠体内6周后丢失率...
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008;30:393–402. Article CAS PubMed Google Scholar Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications...
HIF-2αexpression,cell apoptosis and expressions of key proteins relevant to ER stress and apoptosis were all significantly increased in hypoxia-treated LO2cells,which was effectively inhibited by siRNA.Conclusion HIF-2αcan induce cell apoptosis by activating ER stress signaling pathway under hypoxia ...
Finally, we showed that a newly identified small-molecule inhibitor of HIF-1, NSC-134754, is also able to significantly decrease HIF-2alpha protein expression and HIF-2alpha-regulated VEGF levels in renal carcinoma cells. Our data have important implications for how we target the HIF pathway ...
北京协和医院 基本外科 廖泉 教授等人在2021年12月发表于“Molecular Therapy-Oncolytics”上的文章“Knockdown of LRRN1 inhibits malignant phenotypes through the regulation of HIF-1α/Notch pathway in pan…
HIF1Alpha_Pathway之经典信号通路.ppt,HSP70 HIF1a Pathway Elongin-B Elongin-C Elongin-B p53 MKK3 MKK6 ERK2 FIH1 Ref1 PHD2 PHD1 TCP1a HSP90 MDM2 Ub HIF1a HIF1a HIF1a HIF1a HIF1a HIF1a Per1 JAB1 Ub Ub Ub Ub Ub VHL VHL ARNT HNF4a2 SRC1 HIF1a Degradation HIF1a
DU Y Q, GE Y B, XU Z H, et al. Hypoxia-inducible factor 1 alpha (HIF-1α)/vascular endothelial growth factor (VEGF) pathway participates in angiogenesis of myocardial infarction in muscone-treated mice: preliminary study[J...
factor-1alpha by interleukin-1 beta involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells[J]. Biologyo,reproduction, 2004, 70(6):1822-1827. [7]CramerT, YamanishiY, Clauseen BE, etal. HIF-1alphaisessen-tialfor myeloid cell-mediated inflammation[...
HIF proteins are overexpressed in ccRCC. There are a lot of high impact publications around the VHL-HIF pathway [65,66,67,68]. However, a detailed review to update the VHL-HIF-relevant pathway is not the focus of this review. Instead, we will focus on HIF1α and HIF2α as biomarkers...