可以与上下游多种蛋白组成不同的信号通路,介导低氧信号,调控细胞产生一系列对缺氧的代偿反应, 在机体的生长发育及生理和病理过程中发挥重要作用,是生物医学研究的一个焦点.对转录因子 HIF-1α 及其信号通路在疾病发生 中的作用进行了综述,介绍了 HIF-1α 在动物生长发育,炎症和肿瘤中的研究概况,并进行了展望,以便...
低氧诱导因子(…I:-1Q)在继发性脊髓损伤中的时序 性表达及其意义 一、前言 脊髓损伤(SCI)是一种严重影响人类健康和生活质量的致残性损伤【11。急性 脊髓损伤后开始时常为不完全性,最后结果常为两种损害机制引起:原发性脊髓 损伤和继发性脊髓损伤。脊髓组织遭受机械外力损伤后瞬间引起的组织损害称为 ...
Whole transcriptomic sequencing shows significant upregulation of the hypoxia‐inducible factor 1‐alpha (HIF‐1α) signaling pathway and associated downstream targets. Furthermore, Western blot analysis confirms elevated HIF‐1α protein in Cell Line A cells at later generation. These results suggest ...
hydroxylation of HIF1alpha and this requirement raises the possibility of the involvement of PHD in tumor development.; In this study, we characterize the relationship between PHD and HIF1 activity and cellular transformation using a lineage of the MSU1 cell strains of varying tumorigenic potential....
Based on the results described above, developing pharmacological agents to modulate HIF-1α signaling pathway has recently inspired significant interest. Indeed, several sub-types of drugs has been described to inhibit HIF-1α activity including inhibitors of HIF-1α/HIF-1β dimerization (e.g., ...
Hypoxia Signaling Pathway 缺氧信号通路 动物细胞对氧气的感知和反应是一个非常重要的过程,而缺氧(Hypoxia)是指一种细胞氧气消耗和血管氧气输送失衡,所数的细胞内氧气含量和压力低于正常水平的生理情况,其产生的原因包括低氧血症,氧输送受损和细胞氧吸收受损等等。无论是全身性还是细胞水平上的缺氧,机体都可以利用多种...
Schipani, E. et al. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival.Genes Dev.15, 2865–2876 (2001). CASPubMedPubMed CentralGoogle Scholar Bohensky, J. et al. HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway.Autophagy, ...
signaling pathway focal adhesion P 值 human papillomavirus infection 0.08 0.06 cellular senescence 0.04 0.02 ECM-receptor interaction 基因数 5.0 7.5 10.0 viral protein Malaria interaction with cytokine and cytokine receptor hematopoietic cell lineage antigen processing and presentation p53 signaling pathway ...
MCT1-mediated lactate enhances HIF1α lactylation to stimulate KIAA1199 signaling. Abstract Prostate cancer (PCa) is one of the most prevalent malignancies in adult males. However, PCa is resistant to multi-kinase inhibitors-based anti-angiogenic therapies, and the mechanism and effective targeting...
overexpressing organoids exposed with cisplatin increased cd31 positive structures compared with cisplatin treated organoids, it indicated that the protection of hif-1 alpha on cisplatin induced kidney organoid injury was due to the upregulation of endothelium. oxidative stress is the primary risk factor...