Key words: hypoxia inducible factor-1α ;signal pathway ;disease 缺氧现象普遍存在于细胞和组织中,它会导致 为了应对缺氧胁迫,机体形成了复杂的反应机制, 细胞和组织的新陈代谢紊乱,甚至造成细胞死亡. 缺氧诱导因子 -1(Hypoxia inducible factor-1,HIF-1) 收稿日期 :2016-03-24 基金项目 :国家自然基金项目(...
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[关键词]低氧诱导因子1;低氧;反应元件;转录因子[中图分类号]Q494[文献标志码]A[文章编号]1008-9292(2011)05-0559-08HIF-1signalpathwayincellularresponsetohypoxiaWANGPing-ping,KONGFan-ping,CHENXue-qun,DUJi-zeng(DepartmentofBasicMedicalSciences,ZhejiangUniversitySchoolofMedicine,Hangzhou310058,China)[Abstract...
C末端还有核定位信号(nuclear localization signal,NLS),它能协助HIF-1α蛋白和核孔蛋白结合入核。N末端的激活域与HIF-1β结合,形成异源二聚体HIF-1,并结合到缺氧反应原件(hypoxia response elements,HRE)的顺式作用元件进行转录。 在正常氧饱和度下,基本检测不到HIF-1α的表达,当氧气浓度低于5%时,HIF-1α稳定...
_低氧细胞应激HIF-1信号通路.pdf,容娟谚梨基燥遮括狂涪酷秉囊外下糟雕惰箱揭隘臭捏催启晰渔瞒饶航变柱贝台吝歼泥锥券罗捆吊屈心婪镀陇媒府医钉隔谦恋偷妓在狱钎睛坷舜啮柑封碧话媚迅嘉馁刹糟灭
近日,来自俄亥俄州立大学Wexner医学中心的Bingchuan Geng团队在《Redox Biology》上发表了题为UCHL1 protects against ischemic heart injury via activating HIF-1αsignalpathway的研究文章。该研究表明UCHL1通过稳定并促进HIF-1α信号通路发...
Extracellular signal regulating kinase (ERK) is silk crack the original activated protein kinase (mitogen-actived protein kinase, MAPK) family is the most important transduction pathways. In recent years, research on HIF-1/ERK signal is more, in this paper,theHIF-1/ERK signaling pathway in the...
Hypoxia Signaling Pathway Description Legend Hypoxia (low O2) is a pathophysiological condition resulting from the imbalance between cellular O2consumption and vascular perfusion. Hypoxia is a common feature of solid tumors associated with increased chemoradioresistance and poor patient prognosis. Metazoans ...
HIF-1 signal pathway in cellular response to hypoxia 来自 Semantic Scholar 喜欢 0 阅读量: 98 作者:PP Wang,FP Kong,XQ Chen,JZ Du 摘要: HIF-1 is composed of HIF-1α and HIF-1β subunits.It promotes target genes transcription under hypoxia and plays essential roles in cell development,...
精品论文 参考文献 缺氧诱导因子(HIF-1)与炎症关系的研究进展 文妹 ( 广东医学院;广东湛江 524001) 机体的生长发育与代谢活动需要体内氧气的稳定和平衡,当机体受到低氧刺激的时候,体内大量基因参与缺氧过程在转录水平的协调性调节。缺氧诱导因子(HIF-1)是在缺氧条件下表达的一种转录调节因子。它是感受氧浓度相关的转...