HYPOXIA/HIF-1PATHWAYREGULATETHE INTERACTIONOFCONDITIONALGENE KNOCK-OUTMOUSEOSREOBLASTSAND OSTEOCLASTS ABSTRACT Osteoclastplayacrucialrolesinboneremode,itcomesfrom bonemarrowmononuclearmacrophage.Osteoclastregulatesby RankelandM-CSF,rankelsecredbyosteoblasts.Thepurposeofthe ...
Yue ZhangXiaomei YanKwangmin ChoiGang HuangBloodHayashi Y, Zhang Y, Yan X, et al. HIF-1a pathway, as a signal fun- nel for genetic, epigenetic, and metabolic aberrations, is suffi- cient and essential for MDS development. Blood 2015;126:303....
参考文献 Fengyu Xu et al. LncRNA HIF1A-AS1 promotes gemcitabine resistance of pancreatic cancer by enhancing glycolysis through modulating the AKT/YB1/HIF-1α pathway. Cancer Res 2021 Sep 30;canres.0281.2021. doi: 10.1158/0008-5472.CAN-21-0281. 文章摘自网络,侵删...
Hypoxia-inducibleTranscriptionalPathway.Cancer 4316.4324. 13 Chai Y factor of TF,LeckC,He H.Hypoxia-inducibleindependentdown-regulation in Letters.2011;585:492-498. thioredoxin-interactingproteinhypoxia.FEBS 14 Sohn a1.ERK5MAPK and SJ,SarvisBK,Cado.D,et regulatesembryonicangiogenesis actsasa ofvascular...
HIF inhibitors for cancer therapy target the HIF pathway on different levels: they decrease HIF mRNA or protein levels, inhibit DNA binding or decrease HIF-mediated transactivation (for review, see Fukuda et al.30). It is critical, however, to determine that HIF-1 is the cause for malignant...
HIF-1α regu- lates angiogenesis via Notch1/STAT3/ETBR Pathway in troPhoblastic cells[J]. Cell Cycle (Georgetown, Tex.), 2019, 18(24): 3502-3512. [14] 胡凤丽 . 子痫前期孕妇动脉弹性与氧化应激损伤, 血管内皮功能的相关性 [J]. 中国计划生育学杂志 , 2021, 29(6):1282-1285. HU Fengli. ...
疗效之间的关系;揭示HlF~1a是否能作为预测脑胶质瘤预后的重要指标之一.方法采用免疫组织 化学s—P法检测HlF—la蛋白在52倒脑胶质瘤中的表达;采用局部或全脑+局部放射治疗以研究 HIF一1a表达对18例术后放疗患者1,2年生存率的影响.结果HlF一1a在52例脑胶质瘤中有34 侧表达阳性.阳性表达率为65.39,在病理为Ⅲ~...
Fengyu Xu et al. LncRNA HIF1A-AS1 promotes gemcitabine resistance of pancreatic cancer by enhancing glycolysis through modulating the AKT/YB1/HIF-1α pathway. Cancer Res 2021 Sep 30;canres.0281.2021. doi: 10.1158/0008-5472.CAN-21-0281. ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook HIF1A Wikipedia A gene on chromosome 14q23.2 that encodes hypoxia-inducible factor-1 (HIF1), a transcription factor produced by mammalian cells cultured under reduced oxygen tension, which plays an essential role...
Hypoxia and hypoxia-inducible factor (HIF)-1a signal pathway are potential targets in multiple myelomaN., Giuliani