443种HIF-1信号通路化合物的集合,可用于细胞氧感知相关研究。 规格 预溶于DMSO或水 100uL/well 询价获取超大折扣 全国免费电话:400-668-6834 | Email:info@selleck.cn 您可以选择: 特定分子选择 规格 分子所置板上位置 粉末或DMSO溶液 客户使用该化合物库发表的文献286篇: ...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
英文名称 HIF-1 Signaling Pathway Compound Library 产品介绍 描述及优势 •443种HIF-1信号通路化合物的独特集合,用于高通量筛选(HTS)和高内涵筛选(HCS) •靶点包括HIF,HDAC,PI3K,MAPK,VHL等 •用于探索细胞氧感应的机制 •某些化合物已被FDA批准 •结构多样,具有药用活性且可渗透细胞 详细信息 配制...
signaling. HIF-1 exerts pleiotropic effects on both cancer and stromal cells. For example, HIF-α-dependent expression of VEGF-A and PDGF-B induces angiogenesis by promoting proliferation and migration of pericytes, endothelial and vascular smooth muscle cells. In cancer-associated fibroblasts (CAFs)...
3.2基于HIF-1信号通路分析复方治疗心肌缺血的分子机制 基于前期收集的活性成分潜在靶点,利用DAVID数据库进行单味药材的KEGG通路富集分析, 见表2~5。结果表明黄芪、丹参、三七共有9个共同通路(P<0.05),见图3,其中HIF-1 signaling pathway、PI3K...
【关键词】间充质干细胞动员;DMOG;缺氧诱导因子-1α;基质细胞衍生因子-lα;血管内皮生长因子【中图分类号】R332【文献标识码】A【文章编号】1671-7856(2015)01-0009-06doi:10.3969.j.issn.1671.7856.2015.001.002MechanismofHIF-1signalingpathwayinmediatingMSCsmobilizationwithDMOGHUShao-jun1,YUQin1,LIULi-zhen2,...
Whole transcriptomic sequencing shows significant upregulation of the hypoxia‐inducible factor 1‐alpha (HIF‐1α) signaling pathway and associated downstream targets. Furthermore, Western blot analysis confirms elevated HIF‐1α protein in Cell Line A cells at later generation. These results suggest ...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical.%缺氧诱导...
近 10 年来,有关 HIF- 1 在细胞低氧应激时的信号转导通路,特别是 HIF- 1α 介导的基因转录调控的研究取得了巨大进展。[关键词]低氧诱导因子 1;低氧;反应元件;转录因子Q 494[文献标志码][中图分类号]A[文章编号]1008- 9292( 2011)05- 0559- 08HIF- 1 signal pathway in cellular response to hypoxia...
近10年来,有关HIF-1在细胞低氧应激时的信号转导通路,特别是HIF-1α介导的基因转录调控的研究取得了巨大进展。[关键词]低氧诱导因子1;低氧;反应元件;转录因子[中图分类号]Q494[文献标志码]A[文章编号]1008-9292(2011)05-0559-08HIF-1signalpathwayincellularresponsetohypoxiaWANGPing-ping,KONGFan-ping,CHENXue...