HIF1Alpha_Pathway之经典信号通路.ppt,HSP70 HIF1a Pathway Elongin-B Elongin-C Elongin-B p53 MKK3 MKK6 ERK2 FIH1 Ref1 PHD2 PHD1 TCP1a HSP90 MDM2 Ub HIF1a HIF1a HIF1a HIF1a HIF1a HIF1a Per1 JAB1 Ub Ub Ub Ub Ub VHL VHL ARNT HNF4a2 SRC1 HIF1a Degradation HIF1a
We found that the suppression of HIF-1 alpha expression by melatonin correlated with dephosphorylation of p70S6K and its direct target RPS6, a pathway known to regulate HIF-1 alpha expression at the translational level. Metabolic labeling assays indicated that melatonin inhibits de novo synthesis of...
Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1 alpha pathwayCelastrolHIF-1 alphaAntitumorIn vivoFour series of hypoxia-inducible factor-1 alpha (HIF-1 alpha) functioning derivatives stemming from modifications to the C-29 carboxyl group of celastrol...
Based on the results described above, developing pharmacological agents to modulate HIF-1α signaling pathway has recently inspired significant interest. Indeed, several sub-types of drugs has been described to inhibit HIF-1α activity including inhibitors of HIF-1α/HIF-1β dimerization (e.g., a...
ARTICLEFastinginhibitsaerobicglycolysisandproliferationincolorectalcancerviatheFdft1-mediatedAKT/mTOR/HIF1αpathwaysuppressionMei-linWeng1,11,Wan-kunChen1,2,11,Xiang-yuanChen1,11,HongLu1,Zhi-rongSun1,QiYu3,Peng-feiSun1,Ya-junXu1,Min-minZhu1,NanJiang4,5,JinZhang4,5,Jian-pingZhang6,Yuan-linSong7...
miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma Proc. Natl. Acad. Sci. U. S. A., 111 (2014), pp. 291-296 CrossrefView in ScopusGoogle Scholar [18] W. Yang, J. Wei, T. Guo, et al. Knockdown of miR-210 decreases hypoxic glioma stem cells stemness and radi...
zinc finger protein 91 (zfp91) activates hif-1alpha via nf-kappabp65 to promote proliferation and tumorigenesis of colon.锌指蛋白91(zfp91)激活hif-1alpha通过nf-.pdf 2016-12-21上传 zinc finger protein 91 (zfp91) activates hif-1alpha via nf-kappabp65 to promote proliferation and tumorigenesis ...
HIF-1 alpha Antibody (17-7528-82) in Flow HeLa cells were stimulated overnight with 500 µM Deferoxamine (DFOA). Cells were then fixed and permeabilized with 80% methanol, and intracellularly stained with 0.5 µg of Mouse IgG1 kappa Isotype Control, APC (Product # 17-4714-82) (...
Cancer Stem Cell Markers Cancer Stem Cell Transcription Factors Epigenetics HIF Transcription Factors Intracellular Signaling Molecules in Angiogenesis Transcription Factors in the Akt Pathway Transcription Regulators in VSMC Transcriptional Regulators in Allergy and Asthma...
Considering the regulatory effect of CGA on the HIF-1alpha pathway, the present article systematically elucidates the therapeutic role and molecular mechanisms of HIF-1alpha signaling during the treatment of PCOS by CGA, including follicular development, steroid synthesis, inflammatory response, oxidative...