signaling pathwayhypoxia situationRapid tumor growth is dependent on the capability of tumor blood vessels and glycolysis to provide oxygen and nutrients. Tumor hypoxia is a common characteristic of many solid tumors, and it essentially happens when the growth of the tumor exceeds the concomitant ...
The PI3K/AKT signaling pathway is associated with the generation of calcification in IBC, and it activates the transcription and translation of its downstream hypoxia-inducible factor 1 alpha (HIF1 alpha). Knockdown of HIF1 alpha protein significantly downregulated cell proliferation and migration while...
and glutathione is involved in augmenting or dampening oxidative stress-induced signaling by measuring the expression of the same battery of proteins in the absence and presence of buthionine sulfoximine, an inhibitor of de novo synthesis of glutathione, or in cells lacking HIF-1 signaling pathway. ...
(WGCNA) was performed for DEGs and four significant modules were identified and were enriched Gene Ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways related to immune response, angiogenesis, neuroblast proliferation, HIF-1 signaling pathway, and Parkinson's...
AKT/mTOR pathwaychemokine receptor type 4diffuse large B-cell lymphomahypoxia-inducible factor-1 alphaDiffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy with a high relapse rate. We previously found that C-X-C motif chemokine receptor 4 (CXCR4) was highly expressed in...
The differences were statistically significant.Conclusion Analyses showed that FtMt plays a key role in the vascular regulation of PE trophoblast cells after hypoxia possibly acting via the HIF-1 alpha/VEGF signaling pathway. These results provide us an enhanced understanding of the pathogenesis of PE...
Desferrioxamine, an iron chelator, enhances HIF- 1alpha accumulation via cyclooxygenase-2 signaling pathway. Biochem Biophys Res Commun. 343(1):8-14.Woo KJ,Lee TJ,Park JW,et al.Desferrioxamine,an iron chelator,enhances HIF-1 alpha accumulation via cyclooxygenase-2 signaling pathway[J].Biochem...
ERK Signaling Pathway Is Involved in HPV-16 E6 but not E7 Oncoprotein-Induced HIF-1α Protein Accumulation in NSCLC Cells.Extracellular signal-regulated kinases (ERK) 1/2Human papillomavirusNon-small cell lung cancerAngiogenesisHypoxia-inducible factor-1 alpha...
To sum up, H19 accelerates the tumor formation of endometrial cancer through the miR-20b-5p/AXL/HIF-1 alpha signaling pathway, thereby providing a novel target for diagnosing and treating endometrial cancer.Zhu, HeJin, Yue-MeiLyu, Xue-MenFan, Li-MeiWu, Fei...
In conclusion, our results suggested that HIF-1 alpha-Notch signaling enhanced neurogenesis in acute epilepsy and that neurogenesis during epileptogenesis was reduced once this pathway was blocked; thus, members of this pathway might be potential therapeutic targets for epilepsy. (C) 2018 IBRO. ...