Hedgehog signaling pathwaySMOSonidegibVismodegibPTCHGLISMALL-MOLECULE INHIBITORSBASAL-CELL CARCINOMAPROTEIN-KINASE-APHASE-II TRIALHedgehog (Hh) signaling plays a significant role in embryogenesis and several physiological processes, such as wound healing and organ homeostasis. In a pathological setting, it ...
In adults, aberrant activation of hedgehog signaling has been linked to birth defects and multiple solid cancers. In this review, we assimilate data from recent studies to understand the mechanism of functioning of the hedgehog signaling pathway, role in cancer, its association in various solid ...
Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review) Abstract Hedgehog, BMP/TGFβ, FGF, WNT and Notch signaling pathways constitute the stem cell signaling network, which plays a key role in a variety of processes, such as embryogenesis, maintenance of adult tissue ho...
Here, we review the evolutionarily conserved Hh signalling mechanisms with an emphasis on the functions of the Hh signalling pathway in bone development, homeostasis and diseases. In the early stages of embryonic limb development, Sonic Hedgehog (Shh) acts as a major morphogen in patterning the ...
6. McMillan R, et al. Molecular pathways: the hedgehog signaling pathway in cancer. Clin Cancer Res. 2012;18(18):4883-4888.7. Skoda AM, et al. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosn J Basic Med Sci. 2018;18(1):8-20. Published 2018 Feb ...
6. McMillan R, et al. Molecular pathways: the hedgehog signaling pathway in cancer. Clin Cancer Res. 2012;18(18):4883-4888. 7. Skoda AM, et al. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosn J Basic Med Sci. 2018;18(1):8-20. Published 2018 Feb...
6. McMillan R, et al. Molecular pathways: the hedgehog signaling pathway in cancer. Clin Cancer Res. 2012;18(18):4883-4888. 7. Skoda AM, et al. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosn J Basic Med Sci. 2018...
6. McMillan R, et al. Molecular pathways: the hedgehog signaling pathway in cancer. Clin Cancer Res. 2012;18(18):4883-4888. 7. Skoda AM, et al. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosn J Basic Med Sci. 2018;18(1):8-20. Published 2018 Feb...
6. McMillan R, et al. Molecular pathways: the hedgehog signaling pathway in cancer. Clin Cancer Res. 2012;18(18):4883-4888. 7. Skoda AM, et al. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosn J Basic Med Sci. 2018;18(1):8-20. Published 2018 Feb...
Even more exciting is the discovery and synthesis of specific signaling antagonists for the hedgehog pathway, which have significant clinical implications in novel cancer therapeutics. This review discusses the current understanding of the hedgehog signaling pathway and its activation in human cancers. It...