9. A method of preventing the proliferation, growth, differentiation or survival of cell with an active hedgehog signaling pathway, comprising contacting said cell with an effective amount of a CDC2L1, CSNK1A1,
signalingis a prime example: first discovered through its role in controlling segmental patterning of the epidermis duringDrosophilaembryogenesis, it has subsequently been implicated in a host of other processes in both the larval and adult fly. Moreover, identification of vertebrate homologs, initially...
The minus sign indicates an acidic residue, and (X) indicates the absence of a consensus residue. The percent identity between cos2 and the indicated kinesin family members is shown at the right. COS2 is similar to members of the kinesin protein family (Figure 2C). Over a span of 254 ...
signaling proteins, which, in the mouse, consists of three members: Sonic (Shh), Dhh, and Indian hedgehog (Ihh), all of which share a striking homology with the Drosophila segment polarity gene hedgehog, a key regulator of pattern formation in the embryonic and adult fly (Hammerschmidt et ...
The numbers of mutant or GFP minus cells were counted and are reported as percentages of the total number of glial cells. Average percentages of GFP minus cells are given as mean±SEM. Due to the non-Gaussian distribution of the data, differences between groups have been statistically assessed...