The hedgehog (Hh) signaling pathway is essential for the maintenance of breast CSCs. The present study used immunohistochemistry to investigate the expression of Patched (PTCH) and Gli1, which are the main components of the Hh signaling pathway, as well as the expression of cluster of ...
in this case involving basal cell carcinomas (BCC) of the skin treated with a pharmacologic inhibitor of the Hedgehog-Smoothened (HH/SMO) oncogenic signaling pathway known to drive the neoplastic growth of these cells (33). Drug-resistant cancer...
The Hedgehog (Hh) pathway is a signaling cascade that directs patterning in most animals and is crucial for proper development. At the molecular level, Hh ligands drive cell proliferation in some cell types while causing others to undergo differentiation. Hh signaling is most active during embryoge...
The hedgehog (Hh) signalling pathway is a key regulator of embryonic development, and its deregulation is associated with various birth defects. Although mostly quiescent in adult tissues, Hh signalling has recently been recognized to participate in tissue repair and tumour growth. ...
Targeting the Hedgehog signaling pathway for cancer therapy. Expert Opin Ther Targets 2012;16:49-66.Li, Y., Maitah, M. Y., Ahmad, A., Kong, D., Bao, B., & Sarkar, F. H. (2012). Targeting the Hedgehog signaling pathway for cancer therapy. Expert Opinion on Therapeutic Targets, ...
While hedgehog (Hh) signaling activation has been associated with fibrosis in the lung, kidney, and skin, it is unknown whether hedgehog signaling activation is the cause or the consequence of fibrosis. We hypothesize that activation of hedgehog signaling is sufficient to drive fibrosis in mouse ...
The membrane protein Dispatched (Disp), which belongs to the RND family of small molecule transporters, is essential for Hedgehog (Hh) signaling, by catalyzing the extracellular release of palmitate- and cholesterol-modified Hh ligands from producing cel
The Hedgehog (Hh) signaling pathway regulates a variety of tumor-related diseases, including leukemia. The present study aimed to determine whether there was an interaction between the Hh signaling pathway and transforming growth factor (TGF)-β in the KG-1 cell line. KG-1 cells were treated ...
Hedgehog signaling in the liver Reactivation of Hedgehog (Hh), a morphogenic signaling pathway that controls progenitor cell fate and tissue construction during embryogenesis occurs durin... A Omenetti,S Choi,G Michelotti,... - 《Journal of Hepatology》 被引量: 336发表: 2011年 Hedgehog signaling...
The Hedgehog (HH) signaling pathway The HH signaling pathway is essential for many fundamental processes, including embryogenesis, stem cell maintenance, and tissue regeneration [56]. Some studies indicated that HH signaling plays a broader role in carcinogenesis, such as in breast cancer, gastric ca...