cell signalingcholesterol transportCholesterol plays two critical roles in Hedgehog signaling, a fundamental pathway in animal development and cancer: it covalently modifies the Sonic hedgehog (SHH) ligand, restricting its release from producing cells, and directly activates Smoothened in responding cells. ...
Hedgehog (HH) signaling is crucial for normal development and tissuehomeostasis, and mutations affecting the pathway have been described in congenital malformations and cancers. Key steps in the pathway include ligand production and binding to its receptor, followed by the processing of the GLI transcr...
Regulations of Hedgehog signaling pathway on mesenchymal stem cells. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2010; 24(8): 993–996. 134 Maeda Y, Nakamura E, Nguyen MT et al. Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone....
This allows full activation of Smo and Gli2 to induce high levels of Hh signaling. In the absence of Numb, Ptch1 remains in the cilium even after it binds to Shh. The persistent presence of Ptch1 in the cilium impedes the full activation of the signaling steps downstream of Ptch1. ...
Hedgehog (Hh) signaling is critical for embryonic development and in differentiation, proliferation, and maintenance of multiple adult tissues. Deregulation of the Hh pathway is associated with Multiple pathological steps of PDAC (Pancreatic ductal adenocarcinoma) . A prominent desmoplastic stromal reaction...
The Hedgehog (Hh) signalling pathway plays many important roles in development, homeostasis and tumorigenesis. The critical function of Hh signalling in bone formation has been identified in the past two decades. Here, we review the evolutionarily conser
factorsandhavinggonethroughmanysteps.Resuhingfromtheabnormalactivationofaseriesofproto—onco— geneaswellastheinactivationcausedbymanyanti—oncogenemutation,somesignalpathwaysworkabnor— mally.Inrecentyears,thestudyofHedgehog(Hh),asthesignalpathway,showsthatHhencodesaseries ...
The Hedgehog Signaling Pathway is one of signaling pathways that are very important to embryonic development. The participation of inhibitors in the Hedgehog Signal Pathway can control cell growth and death, and searching novel inhibitors to the functioning of the pathway are in a great demand. As...
Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer Cancer Res., 64 (2004), pp. 6071-6074 View in ScopusGoogle Scholar [26] H. Lemjabbar-Alaoui, V. Dasari, S.S. Sidhu, A. Mengistab, W. Finkbeiner, M. Gallup, C. Basbaum Wnt and Hedgehog are crit...
Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, the most common primary brain tumor, exhibit Hedge