In recent years, it has been found that abnormal expression of Hedgehog signaling pathway-related molecules is involved in a variety of osteoarthropathy. Therefore, studying the relationship between Hedgehog signaling pathway and cartilage damage is of great significance to elucidate the molecular ...
Hedgehog (HH) signaling is crucial for normal development and tissue homeostasis, and mutations affecting the pathway have been described in congenital malformations and cancers. Key steps in the pathway include ligand production and binding to its receptor, followed by the processing of the GLI trans...
factorsandhavinggonethroughmanysteps.Resuhingfromtheabnormalactivationofaseriesofproto—onco—geneaswellastheinactivationcausedbymanyanti—oncogenemutation,somesignalpathwaysworkabnor—mally.Inrecentyears,thestudyofHedgehog(Hh),asthesignalpathway,showsthatHhencodesaseriesofsecretedsignalingprotein,havinganimportant...
Taken together, these data suggest that the Hedgehog signaling pathway promotes the differentiation of multiple neural cell types from ES cells. Discussion In the embryo, the nervous system is established by the progressive commitment of pluripotential cell lineages. A portion of the inner cell mass ...
山东大学硕士学位论文Hedgehog信号通路在非霍奇金淋巴瘤中的表达及临床意义姓名:***请学位级别:硕士专业:内科学(血液病学)指导教师:**20110508山东大学硕十学位论文Hedgehog信号通路在非霍奇金淋巴瘤中的表达及临床意义硕士研究生:张希远专业:内科学(血液病学)指导导师:**教授中文摘要目的非霍奇金淋巴瘤(Non-Hodgkin...
Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, the most common primary brain tumor, exhibit Hedge
This allows full activation of Smo and Gli2 to induce high levels of Hh signaling. In the absence of Numb, Ptch1 remains in the cilium even after it binds to Shh. The persistent presence of Ptch1 in the cilium impedes the full activation of the signaling steps downstream of Ptch1. ...
Acetylation to Ubiquitination Connection in Hh Signaling Acetylation has recently hit the scene of ubiquitination-dependent control of Gli1. Protein acetylation is one of the most critical posttranslational modifications by which crucial steps of cell functions are regulated at molecular level. Two main ...
Hh acts as a morphogen in diverse tissues and uses a largely conserved signaling apparatus at the cell surface to direct multiple cellular fate decisions. The genetic details of the Hh pathway have been characterized extensively, yet a precise mechanistic understanding of the numerous steps involved ...
Hedgehog (Hh) signaling is driven by the cholesterol-modified Hh ligand, generated by autoprocessing of Hh precursor protein. Two steps in Hh autoprocessing, N–S acyl shift and transesterification, must be coupled for efficient Hh cholesteroylation and downstream signal transduction. In the present...