Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway. Neuron. 2009; 62 :349–362. doi: 10.1016/j.neuron.2009.03.022. [ Cross Ref ]Yam PT, Langlois SD, Morin S, Charron F. Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-...
The sonic hedgehog (Shh) pathway is highly activated in a variety of malignancies and plays important roles in tumorigenesis, tumor growth, drug resistance, and metastasis. Our recent study showed that the inhibitors of the Shh pathway such as cyclopamine (CP), a Smothened (SMO) inhibitor, an...
Sonic hedgehog (Shh) pathway Sonic hedgehog is a vertebrate homolog of Hedgehog (Hh) that patterns the segment, leg, wing, eye, and brain in Drosophila. Hh binds to patched (Ptc), a transmembrane protein, and releases its inhibitory effect on downstream smoothened (Smo), which is a G prot...
ChemicalBook 致力于为化学行业用户提供SONIC HEDGEHOG信号通路细胞因子定量分析的性质、化学式、分子式、比重、密度,同时也包括SONIC HEDGEHOG信号通路细胞因子定量分析的沸点、熔点、MSDS、用途、作用、毒性、价格、生产厂家、用途、上游原料、下游产品等信息。
Cellular biology Sonic Hedgehog Signaling Pathway in Amyloid Precursor Protein Trafficking and Proteolysis DREXEL UNIVERSITY Aleister J. Saunders VorobyevaAnna GennadiyAlzheimer's disease (AD) is the most common form of dementia for which there is no cure. AD is characterized by progressive ...
Sonic hedgehog pathway genes are expressed and transcribed in the adult mouse epididymis. J Androl 2004; 25: 514-22.Turner, T. T.; Bomgardner, D.; Jacobs, J. P. Sonic hedge- hog pathway genes are expressed and transcribed in the adult mouse epididymis. J. Androl. 25(4):514-522; ...
近年来,关于Sonic Hedgehog(Shh)通路在IVDD中的研究报道不断出现,Shh信号通路在椎间盘的形成和出生后维持中具有重要作用,并且该通路的表达变化伴随着椎间盘的年龄相关性退行性改变,靶向Shh信号通路可能在IVDD治疗中具有重要意义。本研究对Shh通路在IVD...
Key words:Shh Signaling Pathway, neural tube,spinal cord morphogenesis Hedgehog (Hh)是重要的信号传导途径,而Shh信号通路是其中研究最透彻的。经典的Shh信号通路是由Shh(Sonic hedghog)配体、2个跨膜蛋白受体,以及下游的转录因子Gli蛋白组成。Hedgehog家族蛋白是一类分泌型信号分子,参与中枢神经系统(CNS)、轴旁中胚...
Given that increased interferon-gamma (IFNγ) and Sonic Hedgehog (Shh) expression contribute to cancer development, the role of the Shh signaling pathway as a mediator of IFNγ induced proliferation and recruitment of MSCs was studied. Methods MSCs transduced with lentiviral particles expressing sh...
We also show that ERICH3 ciliary localisations require ARL13B and BBSome components. Finally, ERICH3 loss causes positive (Smoothened) and negative (GPR161) regulators of sonic hedgehog signaling (Shh) to accumulate at abnormally high levels in the cilia of pathway-stimulated cells. Together, ...