The Hedgehog (Hh) signaling pathway is crucial for the development of vertebrate and invertebrate animals alike. Hh ligand binds its receptor Patched (Ptc), allowing the activation of the obligate signal transducer Smoothened (Smo). The levels and localizations of both Ptc and Smo are regulated ...
Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction. Curr Opin Genet Dev 2013; 23(4): 429–437. 30 Gherman A, Davis EE, Katsanis N. The ciliary proteome database: an integrated community resource for the genetic...
HEDGEHOG signaling proteinsGENETIC regulationNEURAL tubeThree recent studies identify mechanisms by which a Hedgehog (HH) gradient can finely tune downstream signalling. HH binding to its receptor leads to the phosphorylation of the transmembrane protein Smoothened (SMO). Li et al. observed that in ...
Fig. 1. Hedgehog signaling. (A) Hh pathway is silent in Hh-responsive cells when Hh ligands are absent. Cells which are capable of responding to Hh ligands (i.e., Hh-responsive cells) express Hh receptors. Patched (Ptc) is the receptor that physically interacts with Hh ligands. In the...
Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. Can. Sci. 2011, 102, 1144-1150. [CrossRef] [PubMed]Hideya Onishi,Masaya Kai,Seiichi Odate.Hypoxia activates the hedgehog signaling pathway in a ligand-...
The Hedgehog (Hh) signalling pathway plays many important roles in development, homeostasis and tumorigenesis. The critical function of Hh signalling in bone formation has been identified in the past two decades. Here, we review the evolutionarily conser
The development of CRC is closely related to the hedgehog signaling pathway. The abnormal activation of the pathway will initiate the binding of Sonic Hedgehog (Shh) to Ptch1 that can trigger the growth of abnormal cells that cause CRC. Traditional Chinese Medicine (TCM) compounds were used to...
Who thinks of naming a gene “Hedgehog”, anyway? The name may be frivolous, but the Hedgehog Signaling Pathway is certainly not, as it is required during the embryogenesis of many organisms. The Hedgehog Signaling Pathway Database, through the San Francisco State University, provides a number ...
The transcription factor of the Hedgehog signaling pathway is Cubitus interruptus (Ci). Ci is a zinc finger transcription factor that is...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough homew...
The Hedgehog (Hh) signaling pathway is crucial for regulating normal cell proliferation and embryonic development [12,13]. Its aberrant activation can result in the onset and development of multiple human cancers, including HCC. Hh signaling can be initiated through the interaction of Hh ligands wit...