Xie, Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene. 29, 469-481 (2010).Yang L; Xie G; Fan Q;.Activation of the hedgehog- signaling pathway in human cancer and the clinical impli- cations.Oncogene.2010.469-481...
11. Niyaz M, et al. Hedgehog Signaling: An Achilles' Heel in Cancer. Transl Oncol. 2019;12(10):1334-1344.12. Bariwal J, et al. Design of Hedgehog pathway inhibitors for cancer treatment. Med Res Rev. 2019;39(3):1137-1204.13. Xin M, Wang B, et al. Strategies to target the ...
13. Xin M, Wang B, et al. Strategies to target the Hedgehog signaling pathway for cancer therapy. Med Res Rev. 2018;38(3):870-913.
The Hedgehog pathway is responsible for regulating and coordinating cellular growth and development in the embryo. Under specific time or position-dependent stimuli, cells secrete the hedgehog family ligands (sonic, desert, and indian), whose binding allows the membrane receptors Patched and Smoothened ...
11. Niyaz M, et al. Hedgehog Signaling: An Achilles' Heel in Cancer. Transl Oncol. 2019;12(10):1334-1344. 12. Bariwal J, et al. Design of Hedgehog pathway inhibitors for cancer treatment. Med Res Rev. 2019;39(3):1137-1204. ...
13. Xin M, Wang B, et al. Strategies to target the Hedgehog signaling pathway for cancer therapy. Med Res Rev. 2018;38(3):870-913. 精彩往期 ◆ 你好,Notch——Notch 通路检测有套路,速来! ◆干货丨Hippo 途径与靶向策略 ◆消逝的记忆——探秘风险因子 APOE4...
6. McMillan R, et al. Molecular pathways: the hedgehog signaling pathway in cancer. Clin Cancer Res. 2012;18(18):4883-4888. 7. Skoda AM, et al. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosn J Basic Med Sci. 2018;18(1):8-20. Published 2018 Feb...
Hedgehog signaling in cancer The Hh pathway has been implicated in the maintenance of stem/progenitor cells in many adult tissues, including the epithelia of many internal organs and brain [4,191]. Not surprisingly, abnormal Hh pathway activation in many of these tissues is associated with tumorig...
Molecular pathways: the hedgehog signaling pathway in cancer. Clin Cancer Res. 2012;18(18):4883-4888.7. Skoda AM, et al. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosn J Basic Med Sci. 2018;18(1):8-20. Published 2018 Feb 20.8. Ingham PW. ...
9. Zeng X, Ju D. Hedgehog Signaling Pathway and Autophagy in Cancer. Int J Mol Sci. 2018;19(8):2279. Published 2018 Aug 3. 10. Blotta S, et al. Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. Blood. 2012;120(25):5002-5013. ...