刺猬信号通路(英文名:Hedgehog signaling pathway)是重要的信号传导通路。 刺猬信号通路是动物发育的关键调控之一,在所有的两侧对称动物中都有表达。刺猬信号通路得名于在其多肽配体--Drosophila果蝇中发现的一种名为Hh 的细胞间信号分子。Hh是 Drosophila体节极性基因的表达物,是果蝇体形发育形成的基础。该分子在后期胚...
Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth and patterning. It exerts its biological effect through a signaling mechanism that terminates at glioma-associated oncogene (GLI) transcrip...
Gli蛋白可以通过与Su(fu)蛋白的抑制物的结合来调节。 The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles i...
The Hedgehog signaling pathway refers to a critical pathway involved in embryogenesis and the regulation of cell renewal and survival. It plays a significant role in regulating the cancer stem cell niche in several human cancers, including prostate cancer. Activation of this pathway leads to the exp...
The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human. Cell Res 1998; 8:15-21.Parisi, M.J., and Lin, H. 1998. The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human. Cell Res. 8...
The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human. Cell Res 1998; 8:15-21.PARISI MICHAEL J; HAIFAN LIN (Depariment of Cell Biology, Box 3709, Duke University,Medical Center Durham, N.C. 27710, USA).The role of the hedgehog/...
The fly hh gene was independently cloned in 1992 by the labs of Jym Mohler, Philip Beachy, and Thomas B. Kornberg. 【参考资料】 1.wekipedia https://http://www..com/doc/5618782848.html,/wiki/Hedgehog_signaling_pathway 2.snapshot http://www..com/doc/5618782848.html,/pb/assets/raw/...
Hedgehog (Hh) pathway plays multiple roles in many physiological processes and its dysregulation leads to congenital disorders and cancers. Hh regulates the cellular localization of Smoothened (Smo) and the stability of Cubitus interruptus (Ci) to fine-tune the signal outputs. However, the underlying...
The fly hh gene was independently cloned in 1992 by the labs of Jym Mohler, Philip Beachy, and Thomas B. Kornberg.【参考资料】1.wekipedia /wiki/Hedgehog_signaling_pathway2.snapshot 3.Hooper J E, Scott M P. Communicating with hedgehogsJ. Nature reviews Molecular cell biology, 2005, 6(4)...
The fly hh gene was independently cloned in 1992 by the labs of Jym Mohler, Philip Beachy, and Thomas B. Kornberg. 【参考资料】 1.wekipedia https://en.wikipedia/wiki/Hedgehog_signaling_pathway 2.snapshot http://.cell/pb/assets/raw/journals/research/snapshots/PIIS0092867407009105.pdf...