GLP-1R被认为是2型糖尿病（T2DM）最为有效的治疗靶点之一。多年的基础研究和临床研究表明GLP-1与受体GLP-1R相互作用，有效调节机体的糖稳态和能量代谢。大量研究已证实，GLP-1R在糖尿病和肥胖症中扮演着重要的调控作用，具有降糖和减重的功能。因此，越来越多的研究者对能够同时抵抗肥胖和降低血糖的GLP-1R表现出了...
3.S. Song, R.Y. Guo, etal, Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis-related NLRP3 pathway, CNS Neurosci. Ther. 28 (3) (2022) 422–434. 免责声明
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3.S. Song, R.Y. Guo, etal, Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis-related NLRP3 pathway, CNS Neurosci. Ther. 28 (3) (2022) 422–434.
[5]Laviola L, Leonardini A, Melchiorre M, et al. Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway. Endocrinology, 2012, 153 : 5770–5781. DOI:10.1210/...
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[31] Drucker, D.J., Campos, R., Reynolds, R., Stobie, K., Brubaker, P.L. 1991. The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells. Endocrinology 128:394-400. [32] Knepel, W., Chafitz, J., Habener, J.F. 1990. Transcriptional...
[5]Laviola L, Leonardini A, Melchiorre M, et al. Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway. Endocrinology, 2012, 153 : 5770–5781. DOI:10.1210/...