Figure 3. Signaling pathways of GLP-1R in pancreatic β-cell [11]除了Gαs /cAMP信号通路，GLP-1R也能偶联其他G蛋白亚型，比如Gαi、 Gαq、 Gαo、 和Gα11。最近的研究表明Gαq通路在胰腺β细胞中具有重要作用。首先，Gαq通路从磷脂酶 C (PLC)的偶联开始，将磷脂酰肌醇4,5-二磷酸 (PIP2) ...
[5]Laviola L, Leonardini A, Melchiorre M, et al. Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway. Endocrinology, 2012, 153 : 5770–5781. DOI:10.1210/...
[15] Bitsi, Stavroula, et al. "Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell–specific β-arrestin 2 knockout mice." Science Advances 9.18 (2023): eadf7737.[16] Challa, Tenagne Delessa, et al. "Regulation of adipocyte formation by GLP-1/GLP-1R sig...
GPCR是近年来药物开发研宄的热门家族靶点,其中,GLP-1R的药物研发已取得显著成功!GLP-1R被认为是2型糖尿病(T2DM)最为有效的治疗靶点之一。多年的基础研究和临床研究表明GLP-1与受体GLP-1R相互作用,有效调节机体的糖稳态和能量代谢。大量研究已证实,GLP-1R在糖尿病和肥胖症中扮演着重要的调控作用,具有降糖和减重的功...
[30] Drucker, D.J., Brubaker, P.L. 1989. Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine. Proc Natl Acad Sci U S A 86:3953-3957. [31] Drucker, D.J., Campos...
[5]Laviola L, Leonardini A, Melchiorre M, et al. Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway. Endocrinology, 2012, 153 : 5770–5781. DOI:10.1210/...
Laviola L, Leonardini A, Melchiorre M, et al. Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway. Endocrinology, 2012, 153 : 5770–5781. DOI:10.1210/en....
3.S. Song, R.Y. Guo, etal, Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis-related NLRP3 pathway, CNS Neurosci. Ther. 28 (3) (2022) 422–434. 免责声明
Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway[J]. Endocrinology, 2012, 153 :5770-5781. [49]Tibaduiza EC, Chen C, Beinborn M. A small molecule ...
[30] Drucker, D.J., Brubaker, P.L. 1989. Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine. Proc Natl Acad Sci U S A 86:3953-3957. [31] Drucker, D.J., Campos, R., Reynolds, R., Stobie, K., Brubaker, P.L. 1991. The rat glucagon ...