研究显示,GLP-1受体激动剂可以与大脑中神经元上的受体结合,尤其是对多巴胺信号通路的影响,且与多巴胺信号通路与大脑的“奖赏回路(reward pathway)”相关,这一回路通常会让我们对高糖和高脂食物产生强烈的渴望。 进一步证实,GLP-1受体激动剂可以“双...
这意味着GLP-1对胰高血糖素分泌的抑制并不完全依赖于生长抑素,GLP-1对胰高血糖素分泌的影响还可以通过forskolin诱导的cAMP变化来模拟。用低浓度forskolin(1~10 nM)处理离体小鼠胰岛可抑制高达60%的胰高血糖素分泌,而高浓度forskolin(0.1~10 μM)...
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[75] t Hart, L.M., Fritsche, A., Nijpels, G., van Leeuwen, N., Donnelly, L.A., Dekker, J.M., et al. 2013. The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway. Diabetes 62:3275-3281. [76] Mussig, K., Staiger, H., Machicao, F., Ha...
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研究结果表明,虽然与安慰剂相比,艾塞那肽并未显着减少大量饮酒的天数,但它确实对腹侧纹状体和间隔区域的 fMRI 酒精提示反应性产生了显着影响。这些大脑区域也和“奖赏回路”(reward pathway)有关,对于药物奖励和成瘾至关重要。 此外,与安慰剂组相比,艾塞那肽组多巴胺转运蛋白的可用性较低。探索性分析显示,艾塞那...
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A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk 2022-07-26, doi: 10.1016/j.celrep.2022.111140 Cell子刊:利用单细胞测序揭示人体消化道中不同细胞类型特征