Woodman, O.L., et al. 2010. Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug ...
Woodman, O.L., et al. 2010. Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening. Mol Pharmacol 78:456-465. ...
[30] Drucker, D.J., Brubaker, P.L. 1989. Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine. Proc Natl Acad Sci U S A 86:3953-3957. [31] Drucker, D.J., Campos, R., Reynolds, R., Stobie, K., Brubaker, P.L. 1991. The rat glucagon g...
1.The aim of this project is to establish a GLP-1 signaling pathway targeted cell model, for screening the new class of GLP-1 receptor agonists as anti-diabetic candidates.建立以GLP-1信号通路为靶点的药物筛选细胞模型,用于筛选GLP-1受体激动剂类的新型抗糖尿病药物。
[31] Dai, C., Hang, Y., Shostak, A., Poffenberger, G., Hart, N., Prasad, N., et al. 2017. Agedependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. J Clin Invest 127:3835-3844. ...
[18] Li, Y., Hansotia, T., Yusta, B., Ris, F., Halban, P.A., Drucker, D.J. 2003. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278:471-478. [19] Park, S., Dong, X., Fisher, T.L., Dunn, S., Omer, A.K., Weir, G., et al...
In non-alcoholic fatty liver disease (NAFLD) mice [23], liraglutide was shown to inhibit the MKK4/JNK signaling pathway, thereby improving the hypoadiponectinemia-induced inflammatory stress. In addition, GLP-1RAs [24] have also been found to play an active role in the treatment of polycystic...
[31] Dai, C., Hang, Y., Shostak, A., Poffenberger, G., Hart, N., Prasad, N., et al. 2017. Agedependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. J Clin Invest 127:3835-384...
A stress signaling pathway in adi-pose tissue regulates hepatic insulin resistance[J]. Science,2008,322( 5907) : 1539-1543. [8]Hotamisligil GS,Spiegelman BM. Tumor necrosis factor-a key com-ponent of the obesity-diabetes link[J]. Diabetes,1994,43 ( 11 ):1271-1278. [9]Moller DE. ...
food intake and body weight. These drugs can reduce the level of C reactive protein and improve inflammation by reducing the release of inflammatory factors,reducing macrophage infiltration and improving inflammation related signaling pathway. In addition,GLP-1 also improves oxidative stress by reducing ...