Glucagon-like peptide-1Migrating myoelectric complexRatSmall intestineEffects of glucagon-like peptide-1 (GLP-1) and glucagon on fasted gut motility in conscious rats were investigated as regards dependence on nitric oxide (NO). Small bowel motility was studied by electromyography and a jugular vein...
39,40 As discussed earlier, the binding of ACE2 to spike glycoprotein of SARS-CoV-2 facilitates viral entry into the cells. Drugs that are used to treat diabetes including glucagon-like peptide-1 (GLP-1) agonists, thiazolidinediones, statins, ACEI, and ARB, are known to elevate ACE2 ...
The glucagon-like peptide-1 receptor agonists (GLP-1RAs) liraglutide and semaglutide reduce cardiovascular risk in type 2 diabetes patients. The mode of action is suggested to occur through modified atherosclerotic progression. In this study, both of the compounds significantly attenuated plaque lesion...
结论:GLP-1可改善高糖诱导的HUVECs凋亡,该抗凋亡作用可能与PI3K/Akt/eNOS通路的上调相关。[关键词]胰高血糖素样肽-1;人脐静脉内皮细胞;高糖;凋亡E ecto GLP-1onhighglucose-inducedhumanumbilicalveinendothelialcellapoptosisandmechanismYUANXiaoyan,CHENKe,HEHonghui,ZHAOLilin,MOZhaohui(Departmento Endocrinology,...
Additionally, geniposidedirectly activated the activity of IDE promoter in PC12 cells, which confirmed the presence of the GLP-1 receptor. All these data show that geniposide upregulating IDE expression through the activation of GLP-1 receptor plays an important role on its neuroprotection to ...
While metformin reduces hepatic glucose production, there is persuasive evidence that the gastrointestinal tract is crucial in mediating this effect, particularly via the secretion of the incretin hormone, glucagon﹍ike peptide 1 (GLP. It is now well recognised that bile acids, in addition to their...
n.1.(Medicine, Biochemistry)The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, themechanism of actionof actinomycin involves its binding to DNA. The mechanism of action is usually considered to include an identifi...
Resveratrol increases glucose induced GLP-1 secretion in mice: A mechanism which contributes to the glycemic control[J]. Plos One,2011,6(6):e20700. doi: 10.1371/journal.pone.0020700 [69] Jun Z, Lili T, Chwan-Li S, et al. Green tea polyphenols modify gut-microbiota dependent metabolism...
Glucagon-like peptide 1 (GLP-1) secretion from intestinal L-cells is triggered by luminal nutrients. We reported previously that glucose-triggered GLP-1 release from the L-cell model GLUTag involves closure of ATP-sensitive K+ (KATP) channels. We show here that GLP-1 secretion and electrical...
Mechanism of Action MOA Video Obesity Is Impacted by Hormones and Can Be Hormonally Treated Similar to native GLP-1, Saxenda®works in the brainato decrease appetite and thereby reduce food intake.1 GLP-1 is a native hormone that is released in response to food intake and acts as a physio...